Polygenic Score (PGS) ID: PGS003438

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: March 3, 2023
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Score Details

Score Construction
PGS Name PRS241_CAD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 241
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000440
Citation (link to publication) Marston NA et al. JAMA Cardiol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1,165,690 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90132314
Europe PMC: 36474045
 1,165,690 individuals European, NR NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017150 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction HR: 1.07 [1.06, 1.08] — — — —
PPM017151 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction in >60 years HR: 1.42 [1.37, 1.48] — — — —
PPM017152 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction in aged 50-60 years HR: 1.46 [1.38, 1.53] — — — —
PPM017153 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Myocardial infarction in < 50 years HR: 1.72 [1.56, 1.89] — — — —
PPM017154 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events — C-index: 0.74 [0.73, 0.74] — — —
PPM017155 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events in >60 years — C-index: 0.68 [0.67, 0.69] — — —
PPM017156 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events in aged 50-60 years — C-index: 0.71 [0.7, 0.73] — — —
PPM017157 PSS010137|
European Ancestry|
330,201 individuals
 PGP000440 |
Marston NA et al. JAMA Cardiol (2023)
 Reported Trait: Atherosclerotic Cardiovascular Disease (ASCVD) events in < 50 years — C-index: 0.76 [0.73, 0.78] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010137 Incident MI was defined by the general International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10), code I21 and its subcodes I210-I214 and I219. — 330,201 individuals,
43.0 % Male samples
 Median = 57.0 years European — UKB —