Polygenic Score (PGS) ID: PGS003450

Predicted Trait
Reported Trait Multiple myeloma
Mapped Trait(s) multiple myeloma (EFO_0001378)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name PRS24_MM
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 24
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000448
Citation (link to publication) Berndt SI et al. Leukemia (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
734,725 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004483
Europe PMC: 27363682
 241,704 individuals European NR
GWAS Catalog: GCST002140
Europe PMC: 23955597
 9,641 individuals European NR
GWAS Catalog: GCST002921
Europe PMC: 26007630
 224,749 individuals European NR
GWAS Catalog: GCST001906
Europe PMC: 23502783
 8,966 individuals European NR
GWAS Catalog: GCST006432
Europe PMC: 30213928
 249,665 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017229 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Chronic lymphocytic leukemia OR: 1.09 [1.02, 1.16] — — — —
PPM017237 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Diffuse large B-cell lymphoma OR: 0.98 [0.93, 1.04] — — — —
PPM017245 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Follicular lymphoma OR: 1.01 [0.95, 1.09] — — — —
PPM017253 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Marginal zone lymphoma OR: 1.05 [0.94, 1.18] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010176 — —
[
  • 10,629 cases
  • , 9,505 controls
]
 — European — NR Inter- Lymph Consortium