Polygenic Score (PGS) ID: PGS003457

Predicted Trait
Reported Trait Intracerebral hemorrhage
Mapped Trait(s) intracerebral hemorrhage (EFO_0005669)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name GRS_ICH
Development Method
Name LDpred2-grid
Parameters h2=0.7288, p=0.1, sparse=FALSE
Variants
Original Genome Build NR
Number of Variants 682,890
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000450
Citation (link to publication) Mayerhofer E et al. Stroke (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
3,026 individuals (100%)
Score Development/Training
European: 100%
862 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002389
Europe PMC: 24656865
3,026 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
[
  • 431 cases
  • , 431 controls
]
,
59.0 % Male samples
European UKB Cases with history of ICH at baseline and the same number of randomly selected age- and sex-matched ICH-free controls. Mean = 60.0 years Mean = 11.9 years

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017258 PSS010179|
Multi-ancestry (including European)|
5,530 individuals
PGP000450 |
Mayerhofer E et al. Stroke (2023)
Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapy HR: 1.24 [1.01, 1.53] : 0.02 age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array
PPM017259 PSS010179|
Multi-ancestry (including European)|
5,530 individuals
PGP000450 |
Mayerhofer E et al. Stroke (2023)
Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapy HR: 1.33 [1.11, 1.59] C-index: 0.57 [0.5, 0.64] age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array, clinical risk score

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010179 The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care data Mean = 11.9 years
[
  • 86 cases
  • , 4,972 controls
]
,
69.0 % Male samples
Mean = 62.0 years European UKB
PSS010179 The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care data Mean = 11.9 years
[
  • 8 cases
  • , 464 controls
]
,
69.0 % Male samples
Mean = 62.0 years Not reported UKB