Polygenic Score (PGS) ID: PGS003499

Predicted Trait
Reported Trait PQ interval
Mapped Trait(s) PR interval (EFO_0004462)
Released in PGS Catalog: April 12, 2023
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Score Details

Score Construction
PGS Name cont-decay-ECG_PQ_interval
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
18,147 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 18,147 individuals,
0.49 % Male samples
 European UKB — Mean = 55.2 years
Sd = 7.4 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017427 PSS010860|
European Ancestry|
995 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM017511 PSS010776|
European Ancestry|
180 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017595 PSS010608|
European Ancestry|
213 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017679 PSS010524|
Greater Middle Eastern Ancestry|
25 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.32 sex, age, deprivation index, PC1-16 —
PPM017763 PSS010188|
European Ancestry|
103 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM017847 PSS010440|
South Asian Ancestry|
159 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017931 PSS010356|
East Asian Ancestry|
73 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018015 PSS010272|
African Ancestry|
49 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM018099 PSS010692|
African Ancestry|
61 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: PQ interval — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010272 — — 49 individuals,
31.0 % Male samples
 Mean = 48.8 years
Sd = 6.4 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010692 — — 61 individuals,
64.0 % Male samples
 Mean = 49.5 years
Sd = 6.5 years		 African unspecified Nigerian UKB —
PSS010440 — — 159 individuals,
65.0 % Male samples
 Mean = 51.1 years
Sd = 8.2 years		 South Asian Indian UKB —
PSS010188 — — 103 individuals,
55.0 % Male samples
 Mean = 56.0 years
Sd = 6.1 years		 European Ashkenazi UKB —
PSS010860 — — 995 individuals,
51.0 % Male samples
 Mean = 55.4 years
Sd = 7.5 years		 European white British UKB —
PSS010608 — — 213 individuals,
48.0 % Male samples
 Mean = 53.8 years
Sd = 7.4 years		 European Italian UKB —
PSS010356 — — 73 individuals,
34.0 % Male samples
 Mean = 50.3 years
Sd = 7.1 years		 East Asian Chinese UKB —
PSS010776 — — 180 individuals,
41.0 % Male samples
 Mean = 53.2 years
Sd = 6.5 years		 European Polish UKB —
PSS010524 — — 25 individuals,
64.0 % Male samples
 Mean = 52.6 years
Sd = 6.8 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —