Polygenic Score (PGS) ID: PGS003501

Predicted Trait
Reported Trait QTc interval
Mapped Trait(s) QT interval (EFO_0004682)
Released in PGS Catalog: April 12, 2023
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Score Details

Score Construction
PGS Name cont-decay-ECG_QTC_interval
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
19,078 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 19,078 individuals,
0.49 % Male samples
 European UKB — Mean = 55.3 years
Sd = 7.4 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017765 PSS010190|
European Ancestry|
107 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017429 PSS010862|
European Ancestry|
1,040 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017513 PSS010778|
European Ancestry|
190 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.08 sex, age, deprivation index, PC1-16 —
PPM017597 PSS010610|
European Ancestry|
219 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017681 PSS010526|
Greater Middle Eastern Ancestry|
26 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017849 PSS010442|
South Asian Ancestry|
165 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017933 PSS010358|
East Asian Ancestry|
72 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM018017 PSS010274|
African Ancestry|
49 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM018101 PSS010694|
African Ancestry|
61 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QTC interval — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010526 — — 26 individuals,
65.0 % Male samples
 Mean = 52.8 years
Sd = 6.8 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010274 — — 49 individuals,
31.0 % Male samples
 Mean = 48.8 years
Sd = 6.4 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010694 — — 61 individuals,
64.0 % Male samples
 Mean = 49.5 years
Sd = 6.5 years		 African unspecified Nigerian UKB —
PSS010442 — — 165 individuals,
66.0 % Male samples
 Mean = 51.1 years
Sd = 8.1 years		 South Asian Indian UKB —
PSS010190 — — 107 individuals,
54.0 % Male samples
 Mean = 56.2 years
Sd = 6.4 years		 European Ashkenazi UKB —
PSS010862 — — 1,040 individuals,
51.0 % Male samples
 Mean = 55.5 years
Sd = 7.5 years		 European white British UKB —
PSS010610 — — 219 individuals,
48.0 % Male samples
 Mean = 53.8 years
Sd = 7.4 years		 European Italian UKB —
PSS010358 — — 72 individuals,
35.0 % Male samples
 Mean = 50.2 years
Sd = 7.1 years		 East Asian Chinese UKB —
PSS010778 — — 190 individuals,
42.0 % Male samples
 Mean = 53.2 years
Sd = 6.4 years		 European Polish UKB —