Polygenic Score (PGS) ID: PGS003505

Predicted Trait
Reported Trait Age at first live birth
Mapped Trait(s) age at first birth measurement (EFO_0009101)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-F_age_first_birth
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
135,632 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 135,632 individuals,
0.0 % Male samples
 European UKB — Mean = 57.5 years
Sd = 7.6 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017601 PSS010614|
European Ancestry|
2,090 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017433 PSS010866|
European Ancestry|
7,313 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017517 PSS010782|
European Ancestry|
1,431 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017769 PSS010194|
European Ancestry|
857 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017853 PSS010446|
South Asian Ancestry|
2,150 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017937 PSS010362|
East Asian Ancestry|
586 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM018021 PSS010278|
African Ancestry|
928 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018105 PSS010698|
African Ancestry|
1,421 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017685 PSS010530|
Greater Middle Eastern Ancestry|
292 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age at first live birth — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010782 — — 1,431 individuals,
0.0 % Male samples
 Mean = 55.4 years
Sd = 7.4 years		 European Polish UKB —
PSS010530 — — 292 individuals,
0.0 % Male samples
 Mean = 53.0 years
Sd = 8.1 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010278 — — 928 individuals,
0.0 % Male samples
 Mean = 53.9 years
Sd = 7.9 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010698 — — 1,421 individuals,
0.0 % Male samples
 Mean = 53.2 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010446 — — 2,150 individuals,
0.0 % Male samples
 Mean = 53.4 years
Sd = 8.0 years		 South Asian Indian UKB —
PSS010866 — — 7,313 individuals,
0.0 % Male samples
 Mean = 57.6 years
Sd = 7.5 years		 European white British UKB —
PSS010194 — — 857 individuals,
0.0 % Male samples
 Mean = 58.5 years
Sd = 6.8 years		 European Ashkenazi UKB —
PSS010614 — — 2,090 individuals,
0.0 % Male samples
 Mean = 55.5 years
Sd = 8.1 years		 European Italian UKB —
PSS010362 — — 586 individuals,
0.0 % Male samples
 Mean = 53.5 years
Sd = 7.5 years		 East Asian Chinese UKB —