Polygenic Score (PGS) ID: PGS003573

Predicted Trait
Reported Trait Qualifications (years of education)
Mapped Trait(s) educational attainment (EFO_0011015)
Released in PGS Catalog: April 12, 2023
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-years_of_edu
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
303,811 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 303,811 individuals,
0.46 % Male samples
 European UKB — Mean = 55.9 years
Sd = 8.0 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017585 PSS010857|
European Ancestry|
3,620 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017669 PSS010689|
European Ancestry|
5,475 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017753 PSS010605|
Greater Middle Eastern Ancestry|
957 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017837 PSS010269|
European Ancestry|
2,170 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017921 PSS010521|
South Asian Ancestry|
4,749 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM018089 PSS010353|
African Ancestry|
1,949 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018173 PSS010773|
African Ancestry|
3,277 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017501 PSS010941|
European Ancestry|
16,423 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018005 PSS010437|
East Asian Ancestry|
1,523 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Qualifications (years of education) — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010689 — — 5,475 individuals,
44.0 % Male samples
 Mean = 53.7 years
Sd = 8.3 years		 European Italian UKB —
PSS010437 — — 1,523 individuals,
32.0 % Male samples
 Mean = 52.3 years
Sd = 7.7 years		 East Asian Chinese UKB —
PSS010857 — — 3,620 individuals,
37.0 % Male samples
 Mean = 54.0 years
Sd = 7.5 years		 European Polish UKB —
PSS010605 — — 957 individuals,
58.0 % Male samples
 Mean = 52.5 years
Sd = 7.9 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010353 — — 1,949 individuals,
32.0 % Male samples
 Mean = 51.2 years
Sd = 7.4 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010941 — — 16,423 individuals,
46.0 % Male samples
 Mean = 55.9 years
Sd = 7.9 years		 European white British UKB —
PSS010773 — — 3,277 individuals,
46.0 % Male samples
 Mean = 51.3 years
Sd = 7.8 years		 African unspecified Nigerian UKB —
PSS010521 — — 4,749 individuals,
56.0 % Male samples
 Mean = 52.9 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010269 — — 2,170 individuals,
45.0 % Male samples
 Mean = 57.7 years
Sd = 7.1 years		 European Ashkenazi UKB —