Polygenic Score (PGS) ID: PGS003574

Predicted Trait
Reported Trait Alzheimer's disease (late onset)
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: April 12, 2023
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Score Details

Score Construction
PGS Name GRS_Dementia21
Development Method
Name Plink 2.0
Parameters genome-wide significant variants p<5x10-8
Variants
Original Genome Build hg19
Number of Variants 21
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000459
Citation (link to publication) Mukadam N et al. PLoS One (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
55,134 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • South Asian
  • African
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002245
Europe PMC: 24162737
 55,134 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018176 PSS010944|
Multi-ancestry (including European)|
378,471 individuals
 PGP000459 |
Mukadam N et al. PLoS One (2022)
 Reported Trait: Dementia OR: 1.21 [1.18, 1.24] — — age, sex, ethnic group, PRS*ethnicity Excluding APOE variants
PPM018175 PSS010944|
Multi-ancestry (including European)|
378,471 individuals
 PGP000459 |
Mukadam N et al. PLoS One (2022)
 Reported Trait: Dementia OR: 1.73 [1.69, 1.77] — — age, sex, ethnic group, PRS*ethnicity —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. —
[
  • 4,729 cases
  • , 360,150 controls
]
,
46.2 % Male samples
 Mean = 56.8 years European
(white British)		 — UKB —
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. —
[
  • 73 cases
  • , 6,592 controls
]
,
54.2 % Male samples
 Mean = 53.4 years South Asian — UKB —
PSS010944 ICD10 codes, including F00, F01, F02, F03 and G30 subcategories. —
[
  • 87 cases
  • , 6,840 controls
]
,
43.6 % Male samples
 Mean = 51.9 years African unspecified
(Black)		 — UKB —