Polygenic Score (PGS) ID: PGS003704

Predicted Trait
Reported Trait Left presubiculum body volume
Mapped Trait(s) presubiculum volume (EFO_0009400)
Released in PGS Catalog: April 28, 2023
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Score Details

Score Construction
PGS Name L_presubiculum_body_UKBB_EUR_GWAS
Development Method
Name PRSice
Parameters The PGS was calculated using PRSice v.2.3.5 software with LD-pruning on the base datasets (clump-kb = 250kb, clump-r2 = 0.1). PRSice performed optimization of the P-value threshold for the most accurate prediction, as measured by r-squared (R2)
Variants
Original Genome Build GRCh37
Number of Variants 17,508
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000464
Citation (link to publication) Yu C et al. Research Square (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
31,968 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
31,968 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018338 PSS010958|
East Asian Ancestry|
1,999 individuals
PGP000464 |
Yu C et al. Research Square (2022)
Reported Trait: Left presubiculum body volume : 0.00397 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010958 1,999 individuals East Asian CHIMGEN