Polygenic Score (PGS) ID: PGS003747

Predicted Trait
Reported Trait Smoking initiation
Mapped Trait(s) smoking initiation (EFO_0005670)
Released in PGS Catalog: June 22, 2023
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Score Details

Score Construction
PGS Name GRS341_SI
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 341
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000471
Citation (link to publication) Tran JH et al. Transl Vis Sci Technol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
931,815 individuals (100%)
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007462
Europe PMC: 30643251
 931,815 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018503 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Any history of smoking OR: 1.2 [1.15, 1.25] — — — —
PPM018504 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Cigarettes per day OR: 0.45 [0.19, 0.7] — — — —
PPM018506 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Open-angle glaucoma OR: 0.84 [0.73, 0.98] — — — —
PPM018507 PSS010997|
Ancestry Not Reported|
14,921 individuals
 PGP000471 |
Tran JH et al. Transl Vis Sci Technol (2023)
 Reported Trait: Intraocular pressure OR: -0.09 [-0.17, -0.01] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010997 — — 14,921 individuals,
40.9 % Male samples
 Mean = 66.1 years Not reported — RS —