Polygenic Score (PGS) ID: PGS003753

Predicted Trait
Reported Trait Attention deficit hyperactivity disorder
Mapped Trait(s) attention deficit hyperactivity disorder (EFO_0003888)
Released in PGS Catalog: June 22, 2023
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Score Details

Score Construction
PGS Name PRS35445_ADHD
Development Method
Name Genome-wide significant SNPs
Parameters r2>0.1, pvalue threshold=0.1412
Variants
Original Genome Build NR
Number of Variants 35,445
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000473
Citation (link to publication) Sato JR et al. Genes Brain Behav (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 96.2%
East Asian: 3.5%
Not Reported: 0.3%
55,374 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007543
Europe PMC: 30478444
 144 individuals Not reported NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
 53,293 individuals European NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
 1,937 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018515 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: ADHD scores from DAWBA questionnaire β: 1.35e-06 — — — —
PPM018516 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (cingulo-opercular network) β: -3e-05 (1.28e-05) — — — —
PPM018517 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (default mode) β: 2e-05 (1.05e-05) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011004 — — 237 individuals,
51.0 % Male samples
 — Hispanic or Latin American
(Brazilian)		 — NR BHRCS