Polygenic Score (PGS) ID: PGS003757

Predicted Trait
Reported Trait Systemic lupus erythematosus
Mapped Trait(s) systemic lupus erythematosus (MONDO_0007915)
Released in PGS Catalog: June 22, 2023
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Score Details

Score Construction
Development Method
Name HLA-DRB1 specific haplotypes
Parameters NR
Original Genome Build NR
Number of Variants 10
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000475
Citation (link to publication) Kwon YC et al. Arthritis Rheumatol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
5,342 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 25533202
  • 849 cases
  • , 4,493 controls
East Asian

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018522 PSS011006|
East Asian Ancestry|
1,655 individuals
PGP000475 |
Kwon YC et al. Arthritis Rheumatol (2023)
Reported Trait: Number of American College of Rheumatology (ACR) criteria for systemic lupus erythematosus β: 0.213 [0.079, 0.347] Onset age, sex, disease duration, and top 4 principal components

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011006 1,655 individuals,
8.4 % Male samples
Mean = 38.1 years
Sd = 12.5 years
East Asian