Polygenic Score (PGS) ID: PGS003762

Predicted Trait
Reported Trait Amyloid beta 42
Mapped Trait(s) beta-amyloid 1-42 measurement (EFO_0004670)
Released in PGS Catalog: Aug. 4, 2023
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Score Details

Score Construction
PGS Name PRS57_amyloid
Development Method
Name Genome-wide significant SNPs
Parameters r2=0.1, pT=0.0001
Variants
Original Genome Build hg19
Number of Variants 57
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000485
Citation (link to publication) Mourtzi N et al. Alzheimers Dement (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
3,149 individuals (100%)
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004069
Europe PMC: 28247064
 3,149 individuals Not reported NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018562 PSS011025|
Ancestry Not Reported|
618 individuals
 PGP000485 |
Mourtzi N et al. Alzheimers Dement (2023)
 Reported Trait: Incidence of Alzheimer's disease/amnestic mild cognitive impairment with high cognitive reserve HR: 0.408 [0.215, 0.775] — — age, sex, PC1, PC2, APOE e4 —
PPM018561 PSS011025|
Ancestry Not Reported|
618 individuals
 PGP000485 |
Mourtzi N et al. Alzheimers Dement (2023)
 Reported Trait: Incidence of Alzheimer's disease/amnestic mild cognitive impairment HR: 1.339 [1.072, 1.672] — — CR, age, sex, PC1, PC2, APOE e4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011025 — Mean = 2.92 years 618 individuals,
41.6 % Male samples
 Mean = 73.37 years
Sd = 4.96 years		 Not reported — HELIAD Hellenic Longitudinal Investigation of Aging and Diet