Polygenic Score (PGS) ID: PGS003861

Predicted Trait
Reported Trait Pulmonary embolism
Mapped Trait(s) pulmonary embolism (EFO_0003827)
Released in PGS Catalog: Sept. 1, 2023
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Score Details

Score Construction
PGS Name PRS288_PE
Development Method
Name PRSice-2
Parameters NR
Variants
Original Genome Build NR
Number of Variants 288
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000499
Citation (link to publication) Zhang Z et al. BMC Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
9,478 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 622 cases
  • , 8,853 controls
]
,
46.04 % Male samples
 East Asian
(Han Chinese)		 CURES_China

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018751 PSS011090|
East Asian Ancestry|
9,456 individuals
 PGP000499 |
Zhang Z et al. BMC Med (2023)
 Reported Trait: Pulmonary embolism — AUROC: 0.765 Odds ratio (OR, 30-70th quantile vs <90th quantile): 5.08 [4.109, 6.282] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011090 — —
[
  • 646 cases
  • , 8,810 controls
]
,
46.34 % Male samples
 — East Asian
(Han Chinese)		 — CURES_China —