Polygenic Score (PGS) ID: PGS003863

Predicted Trait
Reported Trait Lung function (FEV1/FVC)
Mapped Trait(s) FEV/FVC ratio (EFO_0004713)
Released in PGS Catalog: Sept. 1, 2023
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Score Details

Score Construction
PGS Name multiancestry_LF_GRS_FF_weights_AFR
Development Method
Name GRS (weights estimated from MR.MEGA)
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 437
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000500
Citation (link to publication) Shrine N et al. Nat Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
African: 100%
4,363 individuals (100%)
PGS Evaluation
African: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90244093
 4,363 individuals African unspecified ARIC, CHS, MESA

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018753 PSS011093|
African Ancestry|
4,227 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: FEV1/FVC ratio β: 0.1534 [0.1106, 0.1961] — — age, age^2, sex, height, smoking, 10 genetic PCs Beta = Standard deviation (SD) change of FEV1/FVC per SD change of GRS
PPM018757 PSS011091|
African Ancestry|
2,886 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.23 [1.13, 1.34] — — age, age^2, sex, height, smoking —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011091 — —
[
  • 995 cases
  • , 1,891 controls
]
 — African unspecified — COPDGene, SPIROMICS —
PSS011093 — — 4,227 individuals — African unspecified — UKB —