Polygenic Score (PGS) ID: PGS003969

Predicted Trait
Reported Trait Heart failure
Mapped Trait(s) heart failure (EFO_0003144)
Released in PGS Catalog: Oct. 17, 2023
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Score Details

Score Construction
Development Method
Name Genome-wide significant SNPs
Parameters NR
Original Genome Build NR
Number of Variants 39
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000511
Citation (link to publication) Rasooly D et al. Nat Commun (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,266,315 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90274223
Europe PMC: 37429843
1,266,315 individuals European HERMES, MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019123 PSS011190|
European Ancestry|
75,119 individuals
PGP000511 |
Rasooly D et al. Nat Commun (2023)
Reported Trait: Heart failure OR: 1.28 [1.24, 1.31]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 5,845 cases
  • , 69,274 controls
43.9 % Male samples
European BioVU