Polygenic Score (PGS) ID: PGS003973

Predicted Trait
Reported Trait Abdominal aortic aneurysm
Mapped Trait(s) Abdominal Aortic Aneurysm (EFO_0004214)
Released in PGS Catalog: Nov. 1, 2023
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
Development Method
Parameters NR
Original Genome Build NR
Number of Variants 1,118,997
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000513
Citation (link to publication) Roychowdhury T et al. Nat Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 91.9%
African: 8.1%
1,117,811 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
  • 35,973 cases
  • , 991,500 controls
European 11 cohorts
  • ARIC
  • ,CHB
  • ,CHIP
  • ,HUNT
  • ,MGI
  • ,MyCode
  • ,NZ
  • ,PMB
  • ,TABS
  • ,deCODE
  • 2,007 cases
  • , 88,331 controls
African unspecified MVP, eMERGE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019137 PSS011200|
European Ancestry|
7,517 individuals
PGP000513 |
Roychowdhury T et al. Nat Genet (2023)
Reported Trait: Abdominal aortic aneurysm C-index: 0.882 [0.872, 0.892] Age, Age^2, Sex

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 1,241 cases
  • , 6,276 controls
European UKB