Polygenic Score (PGS) ID: PGS003975

Predicted Trait
Reported Trait Low density lipoprotein cholesterol levels
Mapped Trait(s) low density lipoprotein cholesterol measurement (EFO_0004611)
Released in PGS Catalog: Nov. 1, 2023
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Score Details

Score Construction
PGS Name EAS_without-UKB_LDL
Development Method
Name PRS-CSx
Parameters default
Original Genome Build GRCh37
Number of Variants 862,971
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000514
Citation (link to publication) Hassanin E et al. medRxiv (2023) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
146,492 individuals (100%)
PGS Evaluation
East Asian: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90239657
Europe PMC: 34887591
146,492 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019140 PSS011203|
East Asian Ancestry|
1,480 individuals
PGP000514 |
Hassanin E et al. medRxiv (2023)
Reported Trait: LDL level : 8.6 %
PPM019142 PSS011201|
East Asian Ancestry|
68,978 individuals
PGP000514 |
Hassanin E et al. medRxiv (2023)
Reported Trait: LDL level : 9.3 %

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011201 68,978 individuals,
31.2 % Male samples
East Asian Taiwan
PSS011203 1,480 individuals,
36.8 % Male samples
East Asian UKB