Predicted Trait | |
Reported Trait | Prostate cancer |
Mapped Trait(s) | prostate carcinoma (EFO_0001663) |
Score Construction | |
PGS Name | ldpred2.auto.GCST006085.Prostate_cancer |
Development Method | |
Name | LDpred2-auto |
Parameters | auto |
Variants | |
Original Genome Build | GRCh38 |
Number of Variants | 1,045,276 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000517 |
Citation (link to publication) | Monti R et al. Am J Hum Genet (2024) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST006085 Europe PMC: 29892016 |
140,254 individuals | European | NR |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 9,671 individuals, 100.0 % Male samples |
European | UKB | — | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM019545 | PSS011221| European Ancestry| 68,516 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 1.82561 β: 0.60191 |
AUROC: 0.66 | — | 0 | beta = log(or)/sd_pgs |
PPM019546 | PSS011232| European Ancestry| 171,474 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.07696 β: 0.73091 |
AUROC: 0.7 | — | 0 | beta = log(or)/sd_pgs |
PPM019547 | PSS011245| South Asian Ancestry| 19,738 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.12005 β: 0.75144 |
AUROC: 0.71 | — | 0 | beta = log(or)/sd_pgs |
PPM019548 | PSS011261| European Ancestry| 31,410 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 1.93632 β: 0.66079 |
AUROC: 0.68 | — | 0 | beta = log(or)/sd_pgs |
PPM019549 | PSS011289| South Asian Ancestry| 4,976 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.34953 β: 0.85421 |
AUROC: 0.72 | — | 0 | beta = log(or)/sd_pgs |
PPM019550 | PSS011274| European Ancestry| 41,305 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.03998 β: 0.71294 |
AUROC: 0.69 | — | 0 | beta = log(or)/sd_pgs |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011274 | — | — | [ ,
100.0 % Male samples |
— | European | — | UKB | — |
PSS011245 | — | — | [ ,
100.0 % Male samples |
— | South Asian | — | G&H | — |
PSS011221 | — | — | [ ,
100.0 % Male samples |
— | European | — | EB | — |
PSS011289 | — | — | [ ,
100.0 % Male samples |
— | South Asian | — | UKB | — |
PSS011261 | — | — | [ ,
100.0 % Male samples |
— | European | — | HUNT | — |
PSS011232 | C3_PROSTATE, ICD10: C61, ICD9: 185 | — | [ ,
100.0 % Male samples |
— | European | — | FinnGen | — |