Polygenic Score (PGS) ID: PGS004034

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: Dec. 19, 2023
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Terms and Licenses
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Score Details

Score Construction
PGS Name ldpred2.auto.GCST90012877.AD
Development Method
Name LDpred2-auto
Parameters auto
Original Genome Build GRCh38
Number of Variants 1,046,908
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000517
Citation (link to publication) Monti M R et al. medRxiv (2023) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
472,868 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90012877
Europe PMC: 33589840
472,868 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019928 PSS011213|
European Ancestry|
199,274 individuals
PGP000517 |
Monti M R et al. medRxiv (2023)
Reported Trait: AD OR: 1.45859
β: 0.37747
AUROC: 0.61 0 beta = log(or)/sd_pgs
PPM019929 PSS011226|
European Ancestry|
389,004 individuals
PGP000517 |
Monti M R et al. medRxiv (2023)
Reported Trait: AD OR: 1.5321
β: 0.42664
AUROC: 0.62 0 beta = log(or)/sd_pgs
PPM019930 PSS011252|
European Ancestry|
66,865 individuals
PGP000517 |
Monti M R et al. medRxiv (2023)
Reported Trait: AD OR: 1.78882
β: 0.58156
AUROC: 0.67 0 beta = log(or)/sd_pgs

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011226 G6_AD_WIDE, ICD10: G30|F00, ICD9: 3310
  • 13,823 cases
  • , 375,181 controls
European FinnGen
  • 1,562 cases
  • , 65,303 controls
European HUNT
  • 555 cases
  • , 198,719 controls
European EB