Predicted Trait | |
Reported Trait | Alzheimer's disease |
Mapped Trait(s) | Alzheimer disease (MONDO_0004975) |
Score Construction | |
PGS Name | pt_clump.auto.GCST90012877.AD |
Development Method | |
Name | pt_clump.auto |
Parameters | r2 = 0.1, window = 250kb, p = 1e-20 |
Variants | |
Original Genome Build | GRCh38 |
Number of Variants | 58 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000517 |
Citation (link to publication) | Monti M R et al. medRxiv (2023) Preprint |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | European: 100% 472,868 individuals (100%) |
PGS Evaluation | European: 100% 3 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST90012877 Europe PMC: 33589840 |
472,868 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM019919 | PSS011213| European Ancestry| 199,274 individuals |
PGP000517 | Monti M R et al. medRxiv (2023) |Pre |
Reported Trait: AD | OR: 1.27295 β: 0.24134 |
AUROC: 0.57 | — | 0 | beta = log(or)/sd_pgs |
PPM019920 | PSS011226| European Ancestry| 389,004 individuals |
PGP000517 | Monti M R et al. medRxiv (2023) |Pre |
Reported Trait: AD | OR: 1.2393 β: 0.21454 |
AUROC: 0.56 | — | 0 | beta = log(or)/sd_pgs |
PPM019921 | PSS011252| European Ancestry| 66,865 individuals |
PGP000517 | Monti M R et al. medRxiv (2023) |Pre |
Reported Trait: AD | OR: 1.44592 β: 0.36875 |
AUROC: 0.6 | — | 0 | beta = log(or)/sd_pgs |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011226 | G6_AD_WIDE, ICD10: G30|F00, ICD9: 3310 | — | [
|
— | European | — | FinnGen | — |
PSS011252 | — | — | [
|
— | European | — | HUNT | — |
PSS011213 | — | — | [
|
— | European | — | EB | — |