Polygenic Score (PGS) ID: PGS004164

Predicted Trait
Reported Trait Lung cancer in never smokers
Mapped Trait(s)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name PRS16_LC
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-07
Variants
Original Genome Build NR
Number of Variants 16
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000518
Citation (link to publication) Wei X et al. Int J Cancer (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
16,870 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90277434
Europe PMC: 37846649
 16,870 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020095 PSS011294|
East Asian Ancestry|
55,266 individuals
 PGP000518 |
Wei X et al. Int J Cancer (2023)
 Reported Trait: Lung cancer in never smokers HR: 1.28 [1.17, 1.4] — — age, education, BMI, COPD history, personal history of cancer, family history of cancer, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011294 — — 55,266 individuals,
0.0 % Male samples
 — East Asian — CKB —