Polygenic Score (PGS) ID: PGS004224

Predicted Trait
Reported Trait Chronic kidney disease
Mapped Trait(s) chronic kidney disease (EFO_0003884)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name GRS241_CKD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 241
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000524
Citation (link to publication) Lan R et al. Tob Induc Dis (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
625,219 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008065
Europe PMC: 31152163
 625,219 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020162 PSS011300|
Multi-ancestry (including European)|
214,244 individuals
 PGP000524 |
Lan R et al. Tob Induc Dis (2023)
 Reported Trait: Incident CKD with second hand smoke exposure — — Hazard ratio (HR, second hand smoke exposure and high PRS vs. no exposure and low PRS): 1.34 [1.21, 1.48] Age, sex, race, physical activity, Townsend deprivation index, alcohol consumption, total triglyceride, body mass index, hypertension, and diabetes mellitus —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011300 — — 196,354 individuals — European — UKB Full combined ancestry cohort: percent males = 57.9%
PSS011300 — — 17,890 individuals — Not reported — UKB Full combined ancestry cohort: percent males = 57.9%