Polygenic Score (PGS) ID: PGS004317

Predicted Trait
Reported Trait Psoriasis
Mapped Trait(s) psoriasis (EFO_0000676)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
Development Method
Name Genome-wide significant SNPs
Parameters p <5.0E-08
Original Genome Build NR
Number of Variants 77
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000547
Citation (link to publication) Bui A et al. Front Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
287,323 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004346
Europe PMC: 28537254
287,323 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020392 PSS011349|
European Ancestry|
654 individuals
PGP000547 |
Bui A et al. Front Genet (2023)
Reported Trait: Psoriasis in genital area OR: 0.97 [0.94, 1.0]
PPM020395 PSS011348|
European Ancestry|
345 individuals
PGP000547 |
Bui A et al. Front Genet (2023)
Reported Trait: Psoriasis in genital area β: -0.038 (0.019)

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011348 345 individuals,
52.0 % Male samples
Mean = 49.0 years
Sd = 16.0 years
European UCSF
PSS011349 654 individuals,
48.0 % Male samples
Mean = 41.0 years
Sd = 14.0 years
European NR