Polygenic Score (PGS) ID: PGS004324

Predicted Trait
Reported Trait Prurigo nodularis
Mapped Trait(s) prurigo nodularis (MONDO_0026045)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name PRS6314_PN
Development Method
Name Pruning and Thresholding (P+T)
Parameters p<5E-03
Variants
Original Genome Build NR
Number of Variants 6,314
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000558
Citation (link to publication) Vasavda C et al. J Invest Dermatol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
199,049 individuals (100%)
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • African
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
  • Hispanic or Latin American
  • Not Reported
36,499 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90297844
Europe PMC: 37245863
 199,049 individuals European FinnGen
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 171 cases
  • , 36,328 controls
]
 European, African unspecified, Asian unspecified, Oceanian, Hispanic or Latin American, Other, Not reported PHB — Mean = 45.9 years — European (84%), African (5%), Asian unspecified/Pacific Islander (2%), Hispanic (2%), Native American (0.2%), Not reported —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020437 PSS011361|
European Ancestry|
405,582 individuals
 PGP000558 |
Vasavda C et al. J Invest Dermatol (2023)
 Reported Trait: Prurigo nodularis OR: 1.27 — — race, age, and sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011361 — —
[
  • 73 cases
  • , 405,509 controls
]
 — European — UKB —