Polygenic Score (PGS) ID: PGS004325

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung carcinoma (EFO_0001071)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
Development Method
Name Genome-wide significant SNPs
Parameters r2>0.2, p<5e-08
Original Genome Build hg19
Number of Variants 19
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000559
Citation (link to publication) Wang Y et al. Front Physiol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
85,716 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004748
Europe PMC: 28604730
85,716 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020438 PSS011362|
European Ancestry|
308,490 individuals
PGP000559 |
Wang Y et al. Front Physiol (2023)
Reported Trait: Lung carcinogenesis (in smokers) Hazard ratio (HR, highest PRS quintile and heavy smokers vs lowest PRS quintile and never smokers): 4.63 [3.0, 7.13] Education, sex, genotype array, and the first ten important components
PPM020439 PSS011362|
European Ancestry|
308,490 individuals
PGP000559 |
Wang Y et al. Front Physiol (2023)
Reported Trait: Lung carcinogenesis Hazard ratio (HR, highest vs lowest PRS quintiles): 1.58 [1.21, 2.08] Education, sex, genotype array, the first ten primary components, quit time for smokers only, and pack-years for smokers

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 1,449 cases
  • , 307,041 controls
47.0 % Male samples
European UKB