Polygenic Score (PGS) ID: PGS004326

Predicted Trait
Reported Trait Rheumatoid arthritis
Mapped Trait(s) rheumatoid arthritis (EFO_0000685)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name PRS154_RA
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08, r2 < 0.01
Variants
Original Genome Build NR
Number of Variants 154
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000560
Citation (link to publication) Zhang J et al. Environ Health Perspect (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72.1%
East Asian: 27.9%
80,799 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002318
Europe PMC: 24390342
 58,284 individuals European NR
GWAS Catalog: GCST002318
Europe PMC: 24390342
 22,515 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020440 PSS011363|
European Ancestry|
342,973 individuals
 PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
 Reported Trait: Incident rheumatoid arthritis HR: 1.22 [1.17, 1.27] — — age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, first 10 genetic principal components, and genotyping batch. —
PPM020441 PSS011363|
European Ancestry|
342,973 individuals
 PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
 Reported Trait: Incident rheumatoid arthritis with air pollution — — Hazard ratio (HR, high air pollution and PRS in top tertile vs low air pollution and PRS in bottom tertile): 1.73 [1.39, 2.17] age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, first 10 genetic principal components, and genotyping batch. —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011363 ICD10: M05, M06 Median = 8.1 years
[
  • 2,034 cases
  • , 340,939 controls
]
,
46.58 % Male samples
 Mean = 57.0 years
Sd = 7.9 years		 European — UKB —