Polygenic Score (PGS) ID: PGS004586

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal carcinoma (EFO_1001951)
Released in PGS Catalog: June 27, 2024
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Score Details

Score Construction
PGS Name PPS_CRC
Development Method
Name Random survival forest
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 287
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000564
Citation (link to publication) Xin J et al. Nat Commun (2024)
Ancestry Distribution
Score Development/Training
European: 70.8%
East Asian: 29.2%
3,703 individuals (100%)
PGS Evaluation
European: 66.7%
East Asian: 33.3%
3 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 1,082 individuals East Asian
(Chinese)		 NCRCC — — — — NJCRC
— 2,621 individuals European UKB — Mean = 65.25 years — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020702 PSS011374|
East Asian Ancestry|
543 individuals
 PGP000564 |
Xin J et al. Nat Commun (2024)
 Reported Trait: Overall survival of colorectal cancer HR: 1.9 [1.61, 2.24] AUROC: 0.649 — sex, age, smoking status, drinking status and top 10 principal components —
PPM020701 PSS011373|
European Ancestry|
470 individuals
 PGP000564 |
Xin J et al. Nat Commun (2024)
 Reported Trait: Overall survival of colorectal cancer HR: 1.99 [1.57, 2.52] AUROC: 0.652 — sex, age, stage and top 10 principal components —
PPM020703 PSS011372|
European Ancestry|
713 individuals
 PGP000564 |
Xin J et al. Nat Commun (2024)
 Reported Trait: Overall survival of colorectal cancer HR: 1.8 [1.49, 2.17] AUROC: 0.658 — sex, age, smoking status, drinking status, research center, arm, stage, grade and top 10 principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011373 — — 470 individuals — European — TCGA —
PSS011374 — — 543 individuals — East Asian
(Chinese)		 — NCRCC ZJCRC
PSS011372 — — 713 individuals — European — PLCO —