Polygenic Score (PGS) ID: PGS004589

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS80_trans
Development Method
Name Genome-wide significant SNPs
Parameters Nagelkerke R2 = 0.023, P < .001
Original Genome Build NR
Number of Variants 80
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000567
Citation (link to publication) Jung SH et al. JAMA Netw Open (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 88.8%
East Asian: 11.2%
71,962 individuals (100%)
Score Development/Training
East Asian: 100%
1,033 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007511
Europe PMC: 30820047
63,926 individuals European IGAP
GWAS Catalog: GCST012215
Europe PMC: 33654092
8,036 individuals East Asian NCGG
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
  • 554 cases
  • , 479 controls
East Asian

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020712 PSS011377|
East Asian Ancestry|
379 individuals
PGP000567 |
Jung SH et al. JAMA Netw Open (2022)
Reported Trait: Alzheimer's disease dementia OR: 2.09 [1.09, 4.04] Sex, age, education year, 4 PCs, APOE ε4 status

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 159 cases
  • , 220 controls
39.3 % Male samples
Mean = 69.8 years
Sd = 9.3 years
East Asian