Polygenic Score (PGS) ID: PGS004597

Predicted Trait
Reported Trait Ischemic stroke
Mapped Trait(s)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS32_IS
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 32
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000576
Citation (link to publication) Peng H et al. Nutrients (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 85.1%
East Asian: 8.8%
African: 4%
South Asian: 1.8%
Hispanic or Latin American: 0.2%
Additional Asian Ancestries: 0.1%
517,525 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005843
Europe PMC: 29531354
440,328 individuals European NR
GWAS Catalog: GCST005843
Europe PMC: 29531354
45,564 individuals East Asian NR
GWAS Catalog: GCST005843
Europe PMC: 29531354
9,144 individuals South Asian NR
GWAS Catalog: GCST005843
Europe PMC: 29531354
20,687 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST005843
Europe PMC: 29531354
555 individuals Asian unspecified NR
GWAS Catalog: GCST005843
Europe PMC: 29531354
1,247 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020749 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
PGP000576 |
Peng H et al. Nutrients (2023)
Reported Trait: Incident ischaemic stroke in breast cancer survivors Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.25 [0.91, 1.72] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs
PPM020752 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
PGP000576 |
Peng H et al. Nutrients (2023)
Reported Trait: Incident ischaemic stroke in breast cancer survivors with lifestyle Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.37 [0.15, 0.93] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 12,780 individuals,
0.0 % Male samples
European UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 568 individuals,
0.0 % Male samples
Not reported UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)