Polygenic Score (PGS) ID: PGS004605

Predicted Trait
Reported Trait Pulse pressure
Mapped Trait(s) pulse pressure measurement (EFO_0005763)
Released in PGS Catalog: May 22, 2024
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Score Details

Score Construction
PGS Name PP-meta-analysis
Development Method
Name SBayesRC
Parameters Meta-GWAS results were filtered on per-SNP sample size (N) in the range mean_N +- 4 * SD_N
Variants
Original Genome Build GRCh37
Number of Variants 7,356,519
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000581
Citation (link to publication) Keaton JM et al. Nat Genet (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,028,980 individuals (100%)
PGS Evaluation
African: 50%
European: 50%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
1,028,980 individuals European BioVU, ICBP, MVP, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020763 PSS011397|
European Ancestry|
10,210 individuals
PGP000581 |
Keaton JM et al. Nat Genet (2024)
Reported Trait: Pulse pressure : 0.073
beta (high vs low tertile): 10.04
Age, Age2, Sex, BMI
PPM020766 PSS011396|
African Ancestry|
21,843 individuals
PGP000581 |
Keaton JM et al. Nat Genet (2024)
Reported Trait: Pulse pressure beta (high vs low tertile): 5.45 Age, Age2, Sex, BMI

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011396 the earliest median eligible non-Emergency Department outpatient measured SBP in the electronic health record, and the corresponding DBP. For individuals with an even number of SBP measures in their record, the lower value was used to compute the median. For individuals with fewer than three measurements available, the lowest available SBP and corresponding DBP were used. Measures were considered ineligible if they occurred at or after an ICD-9/10 billing code from the groups 585/N18 (chronic kidney disease), 405/I15 (secondary hypertension), or 428/I50 (heart failure). For participants who had started an antihypertensive medication before the date of their median SBP measurement, 15 mm Hg was added to SBP and 10 mm Hg to DBP. Eligible SBP measures were restricted to a range of 30 to 300 mmHg. Eligible DBP measures were restricted to values over 30 mmHg. Eligible DBP measures were restricted to values over 30 mmHg. Sample size for SBP, DBP, and PP GWAS analysis included 21,843 individuals. Pulse pressure was defined as SBP minus DBP. Hypertension status was defined by phecodes 401* and/or antihypertensive medication use. 21,843 individuals,
42.69 % Male samples
Mean = 48.3 years
Sd = 14.75 years
African American or Afro-Caribbean
(American)
AllofUs
PSS011397 In Lifelines, BP was measured every minute during a period of ten minutes using an automated DINAMAP Monitor (GE Healthcare) and the average of the final three readings was recorded for SBP and DBP. Participants with a measured BP ≥140/90 mm Hg irrespective of treatment and those taking antihypertensive medication (ATC codes C02, C03, C07, C08, C09) irrespective of BP were defined as having hypertension. In continuous trait analyses, 15 mm Hg was added to SBP and 10 mm Hg was added to DBP for 1,236 individuals who were taking antihypertensive medication. PP was calculated using these medication-adjusted BP values. 10,210 individuals,
41.6 % Male samples
Mean = 44.66 years
Sd = 13.05 years
European
(Dutch)
LifeLines