Polygenic Score (PGS) ID: PGS004608

Predicted Trait
Reported Trait Neuroticism
Mapped Trait(s) neuroticism measurement (EFO_0007660)
Released in PGS Catalog: Feb. 20, 2024
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name neuroticism
Development Method
Name PRScs-auto
Parameters NR
Variants
Original Genome Build NR
Number of Variants 1,000,537
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000584
Citation (link to publication) Forthman KL et al. J Psychiatr Res (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
380,506 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Additional Diverse Ancestries
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006940
Europe PMC: 29500382
 380,506 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020770 PSS011400|
Multi-ancestry (including European)|
486 individuals
 PGP000584 |
Forthman KL et al. J Psychiatr Res (2023)
 Reported Trait: Repetitive negative thinking — — R²: 0.0275
p-value (inferior to): 0.001		 Age, sex, PCs of predictor features from behavioral and neuropsychological tasks —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011400 — — 321 individuals — European — T1000 —
PSS011400 — — 90 individuals — Native American — T1000 —
PSS011400 — — 31 individuals — African unspecified — T1000 —
PSS011400 — — 20 individuals — Hispanic or Latin American — T1000 —
PSS011400 — — 4 individuals — Asian unspecified — T1000 —
PSS011400 — — 20 individuals — Not reported — T1000 —