Polygenic Score (PGS) ID: PGS004608

Predicted Trait
Reported Trait Neuroticism
Mapped Trait(s) neuroticism measurement (EFO_0007660)
Released in PGS Catalog: Feb. 20, 2024
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Score Details

Score Construction
PGS Name neuroticism
Development Method
Name PRScs-auto
Parameters NR
Original Genome Build NR
Number of Variants 1,000,537
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000584
Citation (link to publication) Forthman KL et al. J Psychiatr Res (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
380,506 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Additional Diverse Ancestries
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006940
Europe PMC: 29500382
380,506 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020770 PSS011400|
Multi-ancestry (including European)|
486 individuals
PGP000584 |
Forthman KL et al. J Psychiatr Res (2023)
Reported Trait: Repetitive negative thinking : 0.0275
p-value (inferior to): 0.001
Age, sex, PCs of predictor features from behavioral and neuropsychological tasks

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011400 321 individuals European T1000
PSS011400 90 individuals Native American T1000
PSS011400 31 individuals African unspecified T1000
PSS011400 20 individuals Hispanic or Latin American T1000
PSS011400 4 individuals Asian unspecified T1000
PSS011400 20 individuals Not reported T1000