Polygenic Score (PGS) ID: PGS004609

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Feb. 20, 2024
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Score Details

Score Construction
PGS Name adult_BMI
Development Method
Name Genome-wide significant SNPs
Parameters r2 ≤ 0.001, distance ≥ 250 kb, 0.01 ≤ MAF ≤ 0.99
Variants
Original Genome Build GRCh37
Number of Variants 1,127
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000585
Citation (link to publication) Hawkes G et al. Diabetologia (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
441,761 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 441,761 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020771 PSS011401|
European Ancestry|
5,774 individuals
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Reported Trait: Adulthood body mass index (at age 44 years) OR: 1.55 [1.43, 1.67] — — — Odds ratio for having a BMI greater than 1 standard deviation from the mean
PPM020772 PSS011402|
European Ancestry|
4,704 individuals
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Reported Trait: Childhood body mass index (at age 11 years) OR: 1.32 [1.2, 1.44] — — — Odds ratio for having a BMI greater than 1 standard deviation from the mean

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011402 — — 4,704 individuals — European — NCDS —
PSS011401 — — 5,774 individuals — European — NCDS —