Polygenic Score (PGS) ID: PGS004612

Predicted Trait
Reported Trait ECG-AI predicted 5-year risk of atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: Feb. 20, 2024
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Score Details

Score Construction
Development Method
Parameters MAF>0.001
Original Genome Build hg19
Number of Variants 1,117,399
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000591
Citation (link to publication) Wang X et al. Circ Genom Precis Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 96.6%
Not Reported: 3.4%
39,986 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90301652
1,369 individuals Not reported UKB
GWAS Catalog: GCST90301652
38,617 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020787 PSS011412|
Multi-ancestry (including European)|
424,411 individuals
PGP000591 |
Wang X et al. Circ Genom Precis Med (2023)
Reported Trait: 5-year incident atrial fibrillation HR: 1.07 [1.04, 1.09] C-index: 0.738 Age at enrollment, sex, genotyping array, 20 PCs of ancestry

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011412 370,121 individuals European UKB
PSS011412 54,290 individuals Not reported UKB