Polygenic Score (PGS) ID: PGS004692

Predicted Trait
Reported Trait Ovarian cancer
Mapped Trait(s) ovarian carcinoma (EFO_0001075)
Released in PGS Catalog: March 18, 2024
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Score Details

Score Construction
PGS Name ovarian_cancer
Development Method
Name AnnoPred
Parameters tier 3; ρ=1e-04
Variants
Original Genome Build hg19
Number of Variants 6,385,666
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000596
Citation (link to publication) Hu J et al. JNCI Cancer Spectr (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
97,898 individuals (100%)
Score Development/Training
European: 100%
198,165 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 28346442
[
  • 29,396 cases
  • , 68,502 controls
]
,
0.0 % Male samples
 European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 983 cases
  • , 197,182 controls
]
,
0.0 % Male samples
 European UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020877 PSS011436|
European Ancestry|
22,025 individuals
 PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
 Reported Trait: Ovarian cancer — AUROC: 0.5298 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011436 — —
[
  • 110 cases
  • , 21,915 controls
]
,
0.0 % Male samples
 — European — UKB —