Polygenic Score (PGS) ID: PGS004861

Predicted Trait
Reported Trait Dilated cardiomyopathy
Mapped Trait(s) dilated cardiomyopathy (EFO_0000407)
Additional Trait Information All DCM
Released in PGS Catalog: April 18, 2024
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Score Details

Score Construction
PGS Name hermes.gwama
Development Method
Name PRS-CS
Parameters Genome-wide
Variants
Original Genome Build hg19
Number of Variants 713,932
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000608
Citation (link to publication) Zheng SL et al. Nat Genet (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
804,997 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 12,700 cases
  • , 792,297 controls
]
 European HERMES

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021092 PSS011521|
European Ancestry|
347,585 individuals
 PGP000608 |
Zheng SL et al. Nat Genet (2024)
 Reported Trait: Dilated cardiomyopathy OR: 1.56 AUROC: 0.7 R²: 0.048 age, age^2, sex, PC1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011521 — —
[
  • 755 cases
  • , 346,830 controls
]
,
45.8 % Male samples
 Mean = 69.8 years European — UKB —