Polygenic Score (PGS) ID: PGS004877

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: June 27, 2024
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Score Details

Score Construction
PGS Name INTERVENE_MegaPRS_Asthma
Development Method
Name megaprs.auto
Parameters bolt, p=0.25, f2=0.1
Variants
Original Genome Build GRCh37
Number of Variants 870,454
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000618
Citation (link to publication) Jermy B et al. Nat Commun (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 97.2%
African: 1.5%
East Asian: 1%
Hispanic or Latin American: 0.3%
536,345 individuals (100%)
Score Development/Training
European: 100%
404 individuals (100%)
PGS Evaluation
European: 100%
7 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST010043
Europe PMC: 32296059
 521,528 individuals European NR
GWAS Catalog: GCST010043
Europe PMC: 32296059
 8,204 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST010043
Europe PMC: 32296059
 1,398 individuals Hispanic or Latin American NR
GWAS Catalog: GCST010043
Europe PMC: 32296059
 5,215 individuals East Asian NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 404 individuals European 1000G — — — non-Finnish Europeans —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021195 PSS011664|
European Ancestry|
33,589 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.27 [1.24, 1.3] C-index: 0.57 [0.57, 0.58] — PCs 1-10 —
PPM021196 PSS011663|
European Ancestry|
69,715 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.48 [1.43, 1.52] C-index: 0.62 [0.61, 0.63] — PCs 1-10 —
PPM021197 PSS011662|
European Ancestry|
29,427 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.47 [1.43, 1.52] C-index: 0.61 [0.6, 0.62] — PCs 1-10 —
PPM021198 PSS011660|
European Ancestry|
44,187 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.39 [1.35, 1.43] — — PCs 1-10 —
PPM021200 PSS011659|
European Ancestry|
412,090 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.42 [1.41, 1.44] C-index: 0.61 [0.61, 0.62] — PCs 1-10 —
PPM021201 PSS011658|
European Ancestry|
199,868 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.35 [1.33, 1.37] C-index: 0.6 [0.6, 0.6] — PCs 1-10 —
PPM021199 PSS011661|
European Ancestry|
7,018 individuals
 PGP000618 |
Jermy B et al. Nat Commun (2024)
 Reported Trait: Incident Asthma HR: 1.41 [1.32, 1.5] C-index: 0.6 [0.58, 0.62] — PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011658 — —
[
  • 23,157 cases
  • , 176,711 controls
]
 — European — EB —
PSS011659 — —
[
  • 45,188 cases
  • , 366,902 controls
]
 — European — FinnGen —
PSS011660 — —
[
  • 4,032 cases
  • , 40,155 controls
]
 — European — G&H —
PSS011661 — —
[
  • 989 cases
  • , 6,029 controls
]
 — European — GS:SFHS —
PSS011662 — —
[
  • 4,346 cases
  • , 25,081 controls
]
 — European — GEL —
PSS011663 — —
[
  • 3,679 cases
  • , 66,036 controls
]
 — European — HUNT —
PSS011664 — —
[
  • 8,184 cases
  • , 25,405 controls
]
 — European — MGBB —