Polygenic Score (PGS) ID: PGS004896

Predicted Trait
Reported Trait Microalbuminuria
Mapped Trait(s) Moderate albuminuria (HP_0012594)
Released in PGS Catalog: May 8, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name mAlb
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 29
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000623
Citation (link to publication) Cañadas-Garre M et al. Int J Mol Sci (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
155,728 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 26631737
 67,452 individuals European ADVANCE_TRIAL
Europe PMC: 21355061
 63,153 individuals European CARDIA, CKDGen, MESA
Europe PMC: 31537649
 19,406 individuals European 14 cohorts
  • AusDiane
  • ,CACTI
  • ,DCCT
  • ,EDC
  • ,EDIC
  • ,FinnDiane
  • ,GENEDIAB
  • ,GoKinD
  • ,JKS
  • ,LatDiane
  • ,LitDiane
  • ,RomDiane
  • ,SDRNT1BIO
  • ,WESDR
GWAS Catalog: GCST005895
Europe PMC: 29703844
 5,717 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021277 PSS011675|
European Ancestry|
389,206 individuals
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Reported Trait: Microalbuminuria OR: 1.014 [1.001, 1.027] — R²: 0.015 Age, sex, BMI, anti-hypertensive medication, cholesterol medication, diabetes, smoking history, insulin —
PPM021280 PSS011675|
European Ancestry|
389,206 individuals
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Reported Trait: Urinary albumin-to-creatinine ratio β: 0.005 (0.002) — R²: 0.093 Age, sex, BMI, anti-hypertensive medication, cholesterol medication, diabetes, smoking history, insulin —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011675 — — 389,206 individuals,
46.1 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European — UKB —