Polygenic Score (PGS) ID: PGS004905

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: May 22, 2024
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Score Details

Score Construction
PGS Name PRS155_AF
Development Method
Name Genome-wide significant SNPs
Parameters r2<0.05, P<5E-08, MAF>0.05
Variants
Original Genome Build NR
Number of Variants 155
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000638
Citation (link to publication) Ma Y et al. Proc Natl Acad Sci U S A (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
  • Additional Asian Ancestries
  • African
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021355 PSS011700|
Multi-ancestry (including European)|
401,251 individuals
 PGP000638 |
Ma Y et al. Proc Natl Acad Sci U S A (2023)
 Reported Trait: Incident atrial fibrillation HR: 2.145 [2.085, 2.205] — — Age, sex, ethnicity, education, employment, alcohol consumption status, smoking status, healthy diet score, physical activity, BMI, hypertension, hyperlipidemia, diabetes, genotyping batch, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011700 — Median = 11.9 years
[
  • 17,096 cases
  • , 358,680 controls
]
 — European — UKB —
PSS011700 — Median = 11.9 years
[
  • 252 cases
  • , 9,451 controls
]
 — Not reported — UKB —
PSS011700 — Median = 11.9 years
[
  • 240 cases
  • , 8,458 controls
]
 — Asian unspecified — UKB —
PSS011700 — Median = 11.9 years
[
  • 143 cases
  • , 6,931 controls
]
 — African unspecified — UKB —