Polygenic Score (PGS) ID: PGS004906

Predicted Trait
Reported Trait Thyroid stimulating hormone concentration
Mapped Trait(s) Thyroid stimulating hormone level (OBA_1000983)
Released in PGS Catalog: May 22, 2024
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Score Details

Score Construction
PGS Name PRS60_TSH
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 60
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000639
Citation (link to publication) Mulder TA et al. Eur J Endocrinol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
54,288 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006899
Europe PMC: 30367059
 54,288 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021356 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Thyroid stimulating hormone concentration β: 0.16 (0.01) — — — —
PPM021357 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Free thyroxine (FT4) concentration β: -0.04 (0.01) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011701 — — 1,680 individuals,
49.3 % Male samples
 Median = 12.1 years
95% Range = [12.0, 12.5] years		 European — BLTS —
PSS011701 — — 2,169 individuals,
50.8 % Male samples
 Median = 6.0 years
95% Range = [5.7, 7.5] years		 European — Generation_R —
PSS011701 — — 3,382 individuals,
52.0 % Male samples
 Median = 7.5 years
95% Range = [7.3, 8.9] years		 European — ALSPAC —