Polygenic Score (PGS) ID: PGS004908

Predicted Trait
Reported Trait Kidney cancer
Mapped Trait(s) renal carcinoma (EFO_0002890)
Released in PGS Catalog: May 22, 2024
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Score Details

Score Construction
PGS Name PRS107_KC
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 107
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000640
Citation (link to publication) Purdue MP et al. Nat Genet (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 82.4%
East Asian: 16.2%
African: 0.7%
Hispanic or Latin American: 0.7%
539,885 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 24,194 cases
  • , 420,476 controls
]
 European FinnGen, NCI
—
[
  • 897 cases
  • , 3,109 controls
]
 African American or Afro-Caribbean NCI
—
[
  • 1,612 cases
  • , 2,180 controls
]
 Hispanic or Latin American NCI
—
[
  • 621 cases
  • , 86,796 controls
]
 East Asian BBJ, NCI

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021361 PSS011702|
European Ancestry|
324,805 individuals
 PGP000640 |
Purdue MP et al. Nat Genet (2024)
 Reported Trait: Kidney cancer OR: 1.5 [1.43, 1.58] AUROC: 0.74 [0.72, 0.75] — Age, sex, PCs, BMI, smoking, hypertension —
PPM021362 PSS011702|
European Ancestry|
324,805 individuals
 PGP000640 |
Purdue MP et al. Nat Genet (2024)
 Reported Trait: Clear cell renal cell carcinoma OR: 1.69 [1.57, 1.81] AUROC: 0.74 [0.72, 0.76] — Age, sex, PCs, BMI, smoking, hypertension —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011702 — —
[
  • 1,696 cases
  • , 323,109 controls
]
 — European — UKB —