Polygenic Score (PGS) ID: PGS004920

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: June 27, 2024
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Score Details

Score Construction
PGS Name GRS166_AF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 166
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000652
Citation (link to publication) Wang N et al. Eur Heart J (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,030,836 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006414
Europe PMC: 30061737
 1,030,836 individuals European AFGen, HUNT, MGI, deCODE, discovEHR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021391 PSS011724|
European Ancestry|
193,819 individuals
 PGP000652 |
Wang N et al. Eur Heart J (2021)
 Reported Trait: Atrial fibrillation HR: 2.68 [2.53, 2.84] — — Age, sex, ethnicity, Townsend index, education, smoking status, BMI <25.0 kg/m2, physical activity goal (≥150 min/week of moderate intensity, ≥75 min/week of vigorous intensity, or an equivalent combination), dietary score ≥4 proposed in previous studies, total cholesterol <5.18 mmol/L without using lipid-lowering medication, glycated haemoglobin <5.7% (39 mmol/mol) and no history of diabetes, blood pressure <120/<80 mmHg without using blood pressure-lowering medication —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011724 — —
[
  • 3,832 cases
  • , 189,987 controls
]
 — European — UKB —