Polygenic Score (PGS) ID: PGS004955

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung carcinoma (EFO_0001071)
Released in PGS Catalog: Sept. 19, 2024
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Score Details

Score Construction
PGS Name PRS23
Development Method
Name Genome-wide significant SNPs
Parameters MAF > 0.5%, r2 < 0.1
Variants
Original Genome Build NR
Number of Variants 23
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000678
Citation (link to publication) Zhu M et al. Int J Epidemiol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
85,716 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004748
Europe PMC: 28604730
 85,716 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021775 PSS011794|
European Ancestry|
406,880 individuals
 PGP000678 |
Zhu M et al. Int J Epidemiol (2023)
 Reported Trait: Incident lung cancer HR: 1.24 [1.19, 1.29] — — Age, sex, smoking status, BMI, highest education level, family history of cancer, personal medical history (previous cancer diagnoses and chronic obstructive pulmonary disease), the forced expiratory volume in 1 second, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011794 — —
[
  • 2,025 cases
  • , 404,855 controls
]
 — European — UKB —