Polygenic Score (PGS) ID: PGS005041

Predicted Trait
Reported Trait Myocardial infarction (PheCode 411.2)
Mapped Trait(s) myocardial infarction (EFO_0000612)
Released in PGS Catalog: Oct. 8, 2024
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Score Details

Score Construction
PGS Name Phe_411_2_prscs_EURss_eurld
Development Method
Name prscs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,273,897
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 50.3%
European: 36%
African: 9.6%
Hispanic or Latin American: 4.1%
1,219,181 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 7,836 cases
  • , 109,218 controls
]
 African American or Afro-Caribbean MVP
—
[
  • 39,613 cases
  • , 399,292 controls
]
 European MVP
—
[
  • 2,989 cases
  • , 46,689 controls
]
 Hispanic or Latin American MVP
—
[
  • 50,758 cases
  • , 562,786 controls
]
 Not reported MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021809 PSS011818|
European Ancestry|
30,379 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Myocardial infarction OR: 1.535 [1.46, 1.62] C-index: 0.78373 — age, sex, 20 PCs —
PPM021816 PSS011798|
African Ancestry|
10,479 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Myocardial infarction OR: 1.247 [1.13, 1.37] C-index: 0.73945 — age, sex, 20 PCs —
PPM021802 PSS011808|
Hispanic or Latin American Ancestry|
8,047 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Myocardial infarction OR: 1.345 [1.19, 1.53] C-index: 0.82428 — age, sex, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011818 — —
[
  • 1,783 cases
  • , 28,596 controls
]
 — European — AllofUs —
PSS011798 — —
[
  • 539 cases
  • , 9,940 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS011808 — —
[
  • 304 cases
  • , 7,743 controls
]
 — Hispanic or Latin American — AllofUs —