Polygenic Score (PGS) ID: PGS005139

Predicted Trait
Reported Trait Asthma
Mapped Trait(s) asthma (MONDO_0004979)
Released in PGS Catalog: Feb. 4, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name forSAS_fromEUR
Development Method
Name PRS-CSx
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 909,320
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000703
Citation (link to publication) Tsuo K et al. Cell Genom (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,376,071 individuals (100%)
PGS Evaluation
Multi-ancestry (excluding European): 100%
  • Additional Asian Ancestries
  • South Asian
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 121,940 cases
  • , 1,254,131 controls
]
 European 14 cohorts
  • BioMe
  • ,BioVU
  • ,CCPM
  • ,EB
  • ,FinnGen
  • ,GS:SFHS
  • ,HUNT
  • ,LifeLines
  • ,MGBB
  • ,MGI
  • ,QSKIN
  • ,UCLA
  • ,UKB
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022359 PSS011919|
Multi-ancestry (excluding European)|
7,976 individuals
 PGP000703 |
Tsuo K et al. Cell Genom (2022)
 Reported Trait: Asthma — — R²: 0.03767 age, sex, 20 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011919 — —
[
  • 1,232 cases
  • , 6,744 controls
]
 — Central Asian, South Asian — UKB —