Polygenic Score (PGS) ID: PGS005167

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: March 17, 2025
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Score Details

Score Construction
PGS Name PRS-PC
Development Method
Name Known susceptibility loci (genome-wide significant SNPs)
Parameters LD r2 ＞ 0.2 ; SNP threshold ＜ 5×10^-8
Variants
Original Genome Build GRCh37
Number of Variants 157
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000711
Citation (link to publication) Zhu M et al. PLoS Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
117,752 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90018685
Europe PMC: 34594039
 90,332 individuals East Asian BBJ
GWAS Catalog: GCST011046
Europe PMC: 33398198
 27,420 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022405 PSS011941|
East Asian Ancestry|
42,860 individuals
 PGP000711 |
Zhu M et al. PLoS Med (2025)
 Reported Trait: Prostate Cancer HR: 1.75 [1.43, 2.15]
β: 0.565		 C-index: 0.658 — Age,Sex (if applicable),Region,Top 10 genetic ancestry principal components The HR and C-index values were derived from Cox proportional hazards regression models.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011941 ICD-10: C61 Median = 11.33 years
Range = [10.18, 12.26] years
[
  • 95 cases
  • , 42,765 controls
]
,
100.0 % Male samples
 Mean = 53.69 years
Sd = 11.01 years		 East Asian
(Chinese)		 — CKB —