Polygenic Score (PGS) ID: PGS005189

Predicted Trait
Reported Trait Monocyte count variance
Mapped Trait(s) monocyte count (EFO_0005091)
Additional Trait Information variance of phenotype
Released in PGS Catalog: May 20, 2025
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Score Details

Score Construction
PGS Name VPGS_MONO
Development Method
Name PRSice-2
Parameters LD-r2 < 0.1 & clumping window=1000kb
Variants
Original Genome Build GRCh37
Number of Variants 9,489,073
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000723
Citation (link to publication) Xiang R et al. Nat Commun (2025)
Ancestry Distribution
Score Development/Training
European: 100%
403,993 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
GWAS Catalog: GCST90565698
 403,993 individuals European
(British)		 UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022544 PSS012000|
European Ancestry|
39,177 individuals
 PGP000723 |
Xiang R et al. Nat Commun (2025)
 Reported Trait: Monocyte_count β: 0.00023 — R²: 0.22394 — effects of PGS*vPGS tested and shown in Supplementary Data 12)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012000 — — 39,177 individuals — European
(British)		 — INTERVAL —