Polygenic Score (PGS) ID: PGS005217

Predicted Trait
Reported Trait Peripheral artery disease
Mapped Trait(s) peripheral arterial disease (EFO_0004265)
Released in PGS Catalog: June 16, 2025
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS_PAD
Development Method
Name LDpred2
Parameters p= [0.0001, 0.00018, 0.00032, 0.001, 0.0018, 0.0032, 0.0056, 0.01, 0.018, 0.032, 0.056, 0.1, 0.18, 0.32, 0.56, 1], h^scale= [0.7, 1, 1.4], Sparse LD = [T, F]
Variants
Original Genome Build hg19
Number of Variants 1,296,292
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000732
Citation (link to publication) Flores AM et al. JAMA Cardiol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 74.5%
Multi-ancestry (including European): 13.9%
  • European
  • Not Reported
East Asian: 6.8%
Multi-ancestry (excluding European): 2.4%
  • East Asian
  • Additional Asian Ancestries
South Asian: 1%
African: 0.7%
Hispanic or Latin American: 0.5%
Additional Diverse Ancestries: 0.06%
Not Reported: 0.02%
8,357,401 individuals (100%)
Score Development/Training
European: 100%
96,239 individuals (100%)
PGS Evaluation
African: 20%
European: 20%
Hispanic or Latin American: 13.3%
East Asian: 13.3%
Greater Middle Eastern: 13.3%
South Asian: 13.3%
Multi-ancestry (including European): 6.7%
  • African
  • East Asian
  • European
  • Greater Middle Eastern
  • South Asian
15 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90132314
Europe PMC: 36474045
 1,165,690 individuals European, NR 8 cohorts
  • CARDIoGRAMplusC4D
  • ,EPIC_CAD
  • ,GerMIFS
  • ,HUNT
  • ,MGBB
  • ,Other
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90092502
Europe PMC: 35165267
 7,894 individuals Sub-Saharan African AWI-Gen
GWAS Catalog: GCST006624
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST006630
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 21,955 individuals Hispanic or Latin American NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 17,127 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 4,647 individuals East Asian, Asian unspecified NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 3,936 individuals Oceanian NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 645 individuals Native American NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 1,025 individuals Not reported NR
GWAS Catalog: GCST008044
Europe PMC: 31217584
 782 individuals Not reported NR
GWAS Catalog: GCST008044
Europe PMC: 31217584
 21,549 individuals Hispanic or Latin American NR
GWAS Catalog: GCST008044
Europe PMC: 31217584
 11,380 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008044
Europe PMC: 31217584
 1,086 individuals East Asian, Asian unspecified NR
GWAS Catalog: GCST008044
Europe PMC: 31217584
 636 individuals Native American NR
GWAS Catalog: GCST90239656
Europe PMC: 34887591
 99,432 individuals African American or Afro-Caribbean, African unspecified 19 cohorts
  • ARIC
  • ,BioMe
  • ,CARDIA
  • ,CFS
  • ,CHOP
  • ,CHS
  • ,HANDLS
  • ,HRS
  • ,HYPERGEN
  • ,HealthABC
  • ,JHS
  • ,JOCO
  • ,JUPITER
  • ,MESA
  • ,MVP
  • ,PMB
  • ,UKB
  • ,WHI
  • ,eMERGE
GWAS Catalog: GCST90239658
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90239660
Europe PMC: 34887591
 40,963 individuals South Asian LOLIPOP, Other, PROMIS, RHS, UKB
GWAS Catalog: GCST90239674
Europe PMC: 34887591
 99,432 individuals African American or Afro-Caribbean, African unspecified 19 cohorts
  • ARIC
  • ,BioMe
  • ,CARDIA
  • ,CFS
  • ,CHOP
  • ,CHS
  • ,HANDLS
  • ,HRS
  • ,HYPERGEN
  • ,HealthABC
  • ,JHS
  • ,JOCO
  • ,JUPITER
  • ,MESA
  • ,MVP
  • ,PMB
  • ,UKB
  • ,WHI
  • ,eMERGE
GWAS Catalog: GCST90239676
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90239678
Europe PMC: 34887591
 40,963 individuals South Asian LOLIPOP, Other, PROMIS, RHS, UKB
GWAS Catalog: GCST90086137
Europe PMC: 33893285
 56,637 individuals European GERA
GWAS Catalog: GCST007458
Europe PMC: 30643251
 341,427 individuals European NR
GWAS Catalog: GCST007459
Europe PMC: 30643251
 377,334 individuals European NR
GWAS Catalog: GCST90104550
Europe PMC: 36180795
 20,924 individuals African American or Afro-Caribbean 10 cohorts
  • ARIC
  • ,CHS
  • ,COMPASS
  • ,INTERSTROKE
  • ,JHS
  • ,MESA
  • ,Other
  • ,REGARDS
  • ,SIGNET
  • ,SiGN
GWAS Catalog: GCST90104545
Europe PMC: 36180795
 256,274 individuals East Asian BBJ, CKB, HISAYAMA, INTERSTROKE, KCPS
GWAS Catalog: GCST90104540
Europe PMC: 36180795
 1,296,908 individuals European Multiple
GWAS Catalog: GCST90018670
Europe PMC: 34594039
 177,713 individuals East Asian BBJ
GWAS Catalog: GCST90018754
Europe PMC: 34594039
 135,808 individuals East Asian BBJ
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 2,086 cases
  • , 94,153 controls
]
 European UKB ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 — — White British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022599 PSS012034|
African Ancestry|
6,939 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.26 [1.01, 1.59] — R²: 0.051 age, sex and the first ten principal components of genetic ancestry —
PPM022600 PSS012035|
East Asian Ancestry|
1,761 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.6 [1.01, 2.53] — R²: 0.11217 age, sex and the first ten principal components of genetic ancestry —
PPM022601 PSS012036|
South Asian Ancestry|
7,680 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.25 [1.07, 1.46] — R²: 0.07629 age, sex and the first ten principal components of genetic ancestry —
PPM022603 PSS012038|
African Ancestry|
51,691 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.11 [1.06, 1.16] — R²: 0.10751 age, sex and the first ten principal components of genetic ancestry —
PPM022604 PSS012039|
East Asian Ancestry|
5,268 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 0.98 [0.78, 1.22] — R²: 0.16129 age, sex and the first ten principal components of genetic ancestry —
PPM022605 PSS012040|
European Ancestry|
119,167 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.25 [1.22, 1.27] — R²: 0.12104 age, sex and the first ten principal components of genetic ancestry —
PPM022606 PSS012041|
Hispanic or Latin American Ancestry|
39,576 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.19 [1.13, 1.25] — R²: 0.15203 age, sex and the first ten principal components of genetic ancestry —
PPM022607 PSS012028|
Greater Middle Eastern Ancestry|
509 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.04 [0.62, 1.75] — R²: 0.31662 age, sex and the first ten principal components of genetic ancestry —
PPM022608 PSS012029|
South Asian Ancestry|
2,289 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.34 [1.02, 1.74] — R²: 0.29674 age, sex and the first ten principal components of genetic ancestry —
PPM022609 PSS012030|
African Ancestry|
1,945 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.24 [0.94, 1.63] — R²: 0.11198 age, sex and the first ten principal components of genetic ancestry —
PPM022610 PSS012031|
European Ancestry|
32,139 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.26 [1.17, 1.34] — R²: 0.11467 age, sex and the first ten principal components of genetic ancestry —
PPM022611 PSS012032|
Hispanic or Latin American Ancestry|
2,933 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.22 [0.89, 1.67] — R²: 0.19935 age, sex and the first ten principal components of genetic ancestry —
PPM022612 PSS012033|
Multi-ancestry (including European)|
304,294 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident peripheral artery disease HR: 1.66 [1.61, 1.71] C-index: 0.731 — age, sex and the first ten principal components of genetic ancestry —
PPM022598 PSS012027|
European Ancestry|
286,356 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.66 [1.62, 1.71] — R²: 0.0888 age, sex and the first ten principal components of genetic ancestry —
PPM022602 PSS012037|
Greater Middle Eastern Ancestry|
7,680 individuals
 PGP000732 |
Flores AM et al. JAMA Cardiol (2025)
 Reported Trait: Incident and prevelant peripheral artery disease OR: 1.62 [1.1, 2.44] — R²: 0.0826 age, sex and the first ten principal components of genetic ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012027 ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 Median = 12.1 years
[
  • 6,205 cases
  • , 280,151 controls
]
 — European — UKB Independent individuals from training sample
PSS012028 ICD-9 Diagnosis: 4400, 44020, 44021, 44022, 44023, 44024, 44029, 44030, 44031, 44032, 4404, 4408, 4439, 4471 ICD-10 Diagnosis: I700, I70201, I70202, I70203, I70209, I70211, I70212, I70213, I70219, I70221, I70222, I70223, I7025, I70229, I70231, I70232, I70233, I70234, I70235, I70238, I70239, I70241, I70242, I70243, I70244, I70245, I70248, I70249, I70261, I70262, I70263, I70269, I70291, I70292, I70293, I70299, I70301, I70302, I70303, I70309, I70311, I70312, I70313, I70319, I70321, I70322, I70323, I70329, I70331, I70332, I70333, I70334, I70335, I70338, I70339, I70341, I70342, I70343, I70344, I70345, I70348, I70349, I70361, I70362, I70363, I70369, I70391, I70392, I70393, I70399, I70401, I70402, I70403, I70409, I70411, I70412, I70413, I70419, I70421, I70422, I70423, I70429, I70431, I70432, I70433, I70434, I70435, I70438, I70439, I70441, I70442, I70443, I70444, I70445, I70448, I70449, I70461, I70462, I70463, I70469, I70491, I70492, I70493, I70499, I70501, I70502, I70503, I70509, I70511, I70512, I70513, I70519, I70521, I70522, I70523, I70529, I70531, I70532, I70533, I70534, I70535, I70538, I70539, I70541, I70542, I70543, I70544, I70545, I70548, I70549, I70561, I70562, I70563, I70569, I70591, I70592, I70593, I70599, I70601, I70602, I70603, I70609, I70611, I70612, I70613, I70619, I70621, I70622, I70623, I70629, I70631, I70632, I70633, I70634, I70635, I70638, I70639, I70641, I70642, I70643, I70644, I70645, I70648, I70649, I70661, I70662, I70663, I70669, I70691, I70692, I70693, I70699, I70701, I70702, I70703, I70709, I70711, I70712, I70713, I70719, I70721, I70722, I70723, I70729, I70731, I70732, I70733, I70734, I70735, I70738, I70739, I70741, I70742, I70743, I70744, I70745, I70748, I70749, I70761, I70762, I70763, I70769, I70791, I70792, I70793, I70799, I7092, I739, I771 CPT: 93668, 27290, 27295, 27590, 27592, 27594, 27596, 27598, 27880, 27881, 27882, 27884, 27886, 27888, 35302, 35303, 35304, 35305, 35306, 35331, 35351, 35355, 35361, 35363, 35371, 35372, 35452, 35454, 35456, 35459, 35470, 35472, 35473, 35474, 35481, 35482, 35483, 35485, 35491, 35492, 35493, 35495, 35521, 35533, 35537, 35538, 35539, 35540, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35637, 35638, 35646, 35647, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35876, 35879, 35881, 35883, 35884, 37220, 37221, 37222, 37223, 37224, 37225, 37226, 37227, 37228, 37229, 37230, 37231, 37232, 37233, 37234, 37235, 35381, 35541, 35546, 35582, 35651, 35641 ICD-9 Procedure: 38.18, 39.25, 39.29, 39.5, 39.9, 84.1, 84.12, 84.13, 84.14, 84.15, 84.16, 84.17, 84.18, 84.19, 84.3 ICD-10 Procedure: 041C***, 041D***, 041F***, 041H***, 041J***, 041K***, 041L***, 041M***, 041N***, 041U***, 0470***, 047C***, 047D***, 047E***, 047F***, 047H***, 047J***, 047K***, 047L***, 047M***, 047N***, 047P***, 047Q***, 047R***, 047S***, 047T***, 047U***, 047V***, 047W***, 047Y***, 04C0***, 04CC***, 04CD***, 04CE***, 04CF***, 04CH***, 04CJ***, 04CK***, 04CL***, 04CM***, 04CN***, 04CP***, 04CQ***, 04CR***, 04CS***, 04CT***, 04CU***, 04CV***, 04CW***, 04CY***, 0Y62***, 0Y63***, 0Y68***, 0Y6C***, 0Y6D***, 0Y6F***, 0Y6G***, 0Y6H***, 0Y6J***, 0Y6M***, 0Y6N*** Median = 2.32 years
[
  • 20 cases
  • , 489 controls
]
 — Greater Middle Eastern (Middle Eastern, North African or Persian) — AllofUs —
PSS012029 ICD-9 Diagnosis: 4400, 44020, 44021, 44022, 44023, 44024, 44029, 44030, 44031, 44032, 4404, 4408, 4439, 4471 ICD-10 Diagnosis: I700, I70201, I70202, I70203, I70209, I70211, I70212, I70213, I70219, I70221, I70222, I70223, I7025, I70229, I70231, I70232, I70233, I70234, I70235, I70238, I70239, I70241, I70242, I70243, I70244, I70245, I70248, I70249, I70261, I70262, I70263, I70269, I70291, I70292, I70293, I70299, I70301, I70302, I70303, I70309, I70311, I70312, I70313, I70319, I70321, I70322, I70323, I70329, I70331, I70332, I70333, I70334, I70335, I70338, I70339, I70341, I70342, I70343, I70344, I70345, I70348, I70349, I70361, I70362, I70363, I70369, I70391, I70392, I70393, I70399, I70401, I70402, I70403, I70409, I70411, I70412, I70413, I70419, I70421, I70422, I70423, I70429, I70431, I70432, I70433, I70434, I70435, I70438, I70439, I70441, I70442, I70443, I70444, I70445, I70448, I70449, I70461, I70462, I70463, I70469, I70491, I70492, I70493, I70499, I70501, I70502, I70503, I70509, I70511, I70512, I70513, I70519, I70521, I70522, I70523, I70529, I70531, I70532, I70533, I70534, I70535, I70538, I70539, I70541, I70542, I70543, I70544, I70545, I70548, I70549, I70561, I70562, I70563, I70569, I70591, I70592, I70593, I70599, I70601, I70602, I70603, I70609, I70611, I70612, I70613, I70619, I70621, I70622, I70623, I70629, I70631, I70632, I70633, I70634, I70635, I70638, I70639, I70641, I70642, I70643, I70644, I70645, I70648, I70649, I70661, I70662, I70663, I70669, I70691, I70692, I70693, I70699, I70701, I70702, I70703, I70709, I70711, I70712, I70713, I70719, I70721, I70722, I70723, I70729, I70731, I70732, I70733, I70734, I70735, I70738, I70739, I70741, I70742, I70743, I70744, I70745, I70748, I70749, I70761, I70762, I70763, I70769, I70791, I70792, I70793, I70799, I7092, I739, I771 CPT: 93668, 27290, 27295, 27590, 27592, 27594, 27596, 27598, 27880, 27881, 27882, 27884, 27886, 27888, 35302, 35303, 35304, 35305, 35306, 35331, 35351, 35355, 35361, 35363, 35371, 35372, 35452, 35454, 35456, 35459, 35470, 35472, 35473, 35474, 35481, 35482, 35483, 35485, 35491, 35492, 35493, 35495, 35521, 35533, 35537, 35538, 35539, 35540, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35637, 35638, 35646, 35647, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35876, 35879, 35881, 35883, 35884, 37220, 37221, 37222, 37223, 37224, 37225, 37226, 37227, 37228, 37229, 37230, 37231, 37232, 37233, 37234, 37235, 35381, 35541, 35546, 35582, 35651, 35641 ICD-9 Procedure: 38.18, 39.25, 39.29, 39.5, 39.9, 84.1, 84.12, 84.13, 84.14, 84.15, 84.16, 84.17, 84.18, 84.19, 84.3 ICD-10 Procedure: 041C***, 041D***, 041F***, 041H***, 041J***, 041K***, 041L***, 041M***, 041N***, 041U***, 0470***, 047C***, 047D***, 047E***, 047F***, 047H***, 047J***, 047K***, 047L***, 047M***, 047N***, 047P***, 047Q***, 047R***, 047S***, 047T***, 047U***, 047V***, 047W***, 047Y***, 04C0***, 04CC***, 04CD***, 04CE***, 04CF***, 04CH***, 04CJ***, 04CK***, 04CL***, 04CM***, 04CN***, 04CP***, 04CQ***, 04CR***, 04CS***, 04CT***, 04CU***, 04CV***, 04CW***, 04CY***, 0Y62***, 0Y63***, 0Y68***, 0Y6C***, 0Y6D***, 0Y6F***, 0Y6G***, 0Y6H***, 0Y6J***, 0Y6M***, 0Y6N*** Median = 2.32 years
[
  • 66 cases
  • , 2,223 controls
]
 — South Asian — AllofUs —
PSS012030 Phenotype constructed using NLP applied to unstructured EHR text and ICD10 codes: Median = 5.19 years
[
  • 58 cases
  • , 1,887 controls
]
 — African American or Afro-Caribbean — MGBB —
PSS012031 Phenotype constructed using NLP applied to unstructured EHR text and ICD10 codes: Median = 5.19 years
[
  • 924 cases
  • , 31,215 controls
]
 — European — MGBB —
PSS012032 Phenotype constructed using NLP applied to unstructured EHR text and ICD10 codes: Median = 5.19 years
[
  • 46 cases
  • , 2,887 controls
]
 — Hispanic or Latin American — MGBB —
PSS012033 ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 Median = 12.1 years
[
  • 6,564 cases
  • , 297,730 controls
]
 — African American or Afro-Caribbean, East Asian, European, Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian — UKB —
PSS012034 ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 Median = 12.1 years
[
  • 126 cases
  • , 6,813 controls
]
 — African unspecified — UKB —
PSS012035 ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 Median = 12.1 years
[
  • 20 cases
  • , 1,741 controls
]
 — East Asian — UKB —
PSS012036 ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 Median = 12.1 years
[
  • 183 cases
  • , 7,497 controls
]
 — South Asian — UKB —
PSS012037 ICD10: I70.0, I70.00, I70.01, I70.2, I70.20, I70.21, I70.8, I70.80, I70.81, I70.9, I70.90, I70.91, I73.8, I73.9 ICD9: 4400, 4402, 4408, 4438, 4439, 9976 OPCS4: X09.1, X09.2, X09.3, X09.4, X09.5, X09.8, X09.9, X10.1, X10.8, X10.9, X12.1, X12.3, X12.4, L16.2, L16.3, L21.6, L25.1, L25.2, L26.1, L26.2, L51.1, L51.2, L51.3, L51.4, L51.6, L51.8, L52.1, L52.2, L54.1, L54.4, L54.8, L54.9, L59.1, L59.2, L59.3, L59.4, L59.5, L59.6, L59.7, L59.8, L59.9, L60.1, L60.2, L60.3, L60.4, L60.8, L60.9, L63.1, L63.5, L63.8, L63.9, L66.5, L66.7, L66.8, L66.9, L68.1, L68.2, L71.1, L71.5, L71.7, L71.8, L71.9 OPCS3: 873, 874, 881, 8841 Median = 12.1 years
[
  • 183 cases
  • , 7,497 controls
]
 — Greater Middle Eastern (Middle Eastern, North African or Persian) — UKB —
PSS012038 ICD-9 Diagnosis: 4400, 44020, 44021, 44022, 44023, 44024, 44029, 44030, 44031, 44032, 4404, 4408, 4439, 4471 ICD-10 Diagnosis: I700, I70201, I70202, I70203, I70209, I70211, I70212, I70213, I70219, I70221, I70222, I70223, I7025, I70229, I70231, I70232, I70233, I70234, I70235, I70238, I70239, I70241, I70242, I70243, I70244, I70245, I70248, I70249, I70261, I70262, I70263, I70269, I70291, I70292, I70293, I70299, I70301, I70302, I70303, I70309, I70311, I70312, I70313, I70319, I70321, I70322, I70323, I70329, I70331, I70332, I70333, I70334, I70335, I70338, I70339, I70341, I70342, I70343, I70344, I70345, I70348, I70349, I70361, I70362, I70363, I70369, I70391, I70392, I70393, I70399, I70401, I70402, I70403, I70409, I70411, I70412, I70413, I70419, I70421, I70422, I70423, I70429, I70431, I70432, I70433, I70434, I70435, I70438, I70439, I70441, I70442, I70443, I70444, I70445, I70448, I70449, I70461, I70462, I70463, I70469, I70491, I70492, I70493, I70499, I70501, I70502, I70503, I70509, I70511, I70512, I70513, I70519, I70521, I70522, I70523, I70529, I70531, I70532, I70533, I70534, I70535, I70538, I70539, I70541, I70542, I70543, I70544, I70545, I70548, I70549, I70561, I70562, I70563, I70569, I70591, I70592, I70593, I70599, I70601, I70602, I70603, I70609, I70611, I70612, I70613, I70619, I70621, I70622, I70623, I70629, I70631, I70632, I70633, I70634, I70635, I70638, I70639, I70641, I70642, I70643, I70644, I70645, I70648, I70649, I70661, I70662, I70663, I70669, I70691, I70692, I70693, I70699, I70701, I70702, I70703, I70709, I70711, I70712, I70713, I70719, I70721, I70722, I70723, I70729, I70731, I70732, I70733, I70734, I70735, I70738, I70739, I70741, I70742, I70743, I70744, I70745, I70748, I70749, I70761, I70762, I70763, I70769, I70791, I70792, I70793, I70799, I7092, I739, I771 CPT: 93668, 27290, 27295, 27590, 27592, 27594, 27596, 27598, 27880, 27881, 27882, 27884, 27886, 27888, 35302, 35303, 35304, 35305, 35306, 35331, 35351, 35355, 35361, 35363, 35371, 35372, 35452, 35454, 35456, 35459, 35470, 35472, 35473, 35474, 35481, 35482, 35483, 35485, 35491, 35492, 35493, 35495, 35521, 35533, 35537, 35538, 35539, 35540, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35637, 35638, 35646, 35647, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35876, 35879, 35881, 35883, 35884, 37220, 37221, 37222, 37223, 37224, 37225, 37226, 37227, 37228, 37229, 37230, 37231, 37232, 37233, 37234, 37235, 35381, 35541, 35546, 35582, 35651, 35641 ICD-9 Procedure: 38.18, 39.25, 39.29, 39.5, 39.9, 84.1, 84.12, 84.13, 84.14, 84.15, 84.16, 84.17, 84.18, 84.19, 84.3 ICD-10 Procedure: 041C***, 041D***, 041F***, 041H***, 041J***, 041K***, 041L***, 041M***, 041N***, 041U***, 0470***, 047C***, 047D***, 047E***, 047F***, 047H***, 047J***, 047K***, 047L***, 047M***, 047N***, 047P***, 047Q***, 047R***, 047S***, 047T***, 047U***, 047V***, 047W***, 047Y***, 04C0***, 04CC***, 04CD***, 04CE***, 04CF***, 04CH***, 04CJ***, 04CK***, 04CL***, 04CM***, 04CN***, 04CP***, 04CQ***, 04CR***, 04CS***, 04CT***, 04CU***, 04CV***, 04CW***, 04CY***, 0Y62***, 0Y63***, 0Y68***, 0Y6C***, 0Y6D***, 0Y6F***, 0Y6G***, 0Y6H***, 0Y6J***, 0Y6M***, 0Y6N*** Median = 2.32 years
[
  • 3,043 cases
  • , 48,648 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012039 ICD-9 Diagnosis: 4400, 44020, 44021, 44022, 44023, 44024, 44029, 44030, 44031, 44032, 4404, 4408, 4439, 4471 ICD-10 Diagnosis: I700, I70201, I70202, I70203, I70209, I70211, I70212, I70213, I70219, I70221, I70222, I70223, I7025, I70229, I70231, I70232, I70233, I70234, I70235, I70238, I70239, I70241, I70242, I70243, I70244, I70245, I70248, I70249, I70261, I70262, I70263, I70269, I70291, I70292, I70293, I70299, I70301, I70302, I70303, I70309, I70311, I70312, I70313, I70319, I70321, I70322, I70323, I70329, I70331, I70332, I70333, I70334, I70335, I70338, I70339, I70341, I70342, I70343, I70344, I70345, I70348, I70349, I70361, I70362, I70363, I70369, I70391, I70392, I70393, I70399, I70401, I70402, I70403, I70409, I70411, I70412, I70413, I70419, I70421, I70422, I70423, I70429, I70431, I70432, I70433, I70434, I70435, I70438, I70439, I70441, I70442, I70443, I70444, I70445, I70448, I70449, I70461, I70462, I70463, I70469, I70491, I70492, I70493, I70499, I70501, I70502, I70503, I70509, I70511, I70512, I70513, I70519, I70521, I70522, I70523, I70529, I70531, I70532, I70533, I70534, I70535, I70538, I70539, I70541, I70542, I70543, I70544, I70545, I70548, I70549, I70561, I70562, I70563, I70569, I70591, I70592, I70593, I70599, I70601, I70602, I70603, I70609, I70611, I70612, I70613, I70619, I70621, I70622, I70623, I70629, I70631, I70632, I70633, I70634, I70635, I70638, I70639, I70641, I70642, I70643, I70644, I70645, I70648, I70649, I70661, I70662, I70663, I70669, I70691, I70692, I70693, I70699, I70701, I70702, I70703, I70709, I70711, I70712, I70713, I70719, I70721, I70722, I70723, I70729, I70731, I70732, I70733, I70734, I70735, I70738, I70739, I70741, I70742, I70743, I70744, I70745, I70748, I70749, I70761, I70762, I70763, I70769, I70791, I70792, I70793, I70799, I7092, I739, I771 CPT: 93668, 27290, 27295, 27590, 27592, 27594, 27596, 27598, 27880, 27881, 27882, 27884, 27886, 27888, 35302, 35303, 35304, 35305, 35306, 35331, 35351, 35355, 35361, 35363, 35371, 35372, 35452, 35454, 35456, 35459, 35470, 35472, 35473, 35474, 35481, 35482, 35483, 35485, 35491, 35492, 35493, 35495, 35521, 35533, 35537, 35538, 35539, 35540, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35637, 35638, 35646, 35647, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35876, 35879, 35881, 35883, 35884, 37220, 37221, 37222, 37223, 37224, 37225, 37226, 37227, 37228, 37229, 37230, 37231, 37232, 37233, 37234, 37235, 35381, 35541, 35546, 35582, 35651, 35641 ICD-9 Procedure: 38.18, 39.25, 39.29, 39.5, 39.9, 84.1, 84.12, 84.13, 84.14, 84.15, 84.16, 84.17, 84.18, 84.19, 84.3 ICD-10 Procedure: 041C***, 041D***, 041F***, 041H***, 041J***, 041K***, 041L***, 041M***, 041N***, 041U***, 0470***, 047C***, 047D***, 047E***, 047F***, 047H***, 047J***, 047K***, 047L***, 047M***, 047N***, 047P***, 047Q***, 047R***, 047S***, 047T***, 047U***, 047V***, 047W***, 047Y***, 04C0***, 04CC***, 04CD***, 04CE***, 04CF***, 04CH***, 04CJ***, 04CK***, 04CL***, 04CM***, 04CN***, 04CP***, 04CQ***, 04CR***, 04CS***, 04CT***, 04CU***, 04CV***, 04CW***, 04CY***, 0Y62***, 0Y63***, 0Y68***, 0Y6C***, 0Y6D***, 0Y6F***, 0Y6G***, 0Y6H***, 0Y6J***, 0Y6M***, 0Y6N*** Median = 2.32 years
[
  • 114 cases
  • , 5,154 controls
]
 — East Asian — AllofUs —
PSS012040 ICD-9 Diagnosis: 4400, 44020, 44021, 44022, 44023, 44024, 44029, 44030, 44031, 44032, 4404, 4408, 4439, 4471 ICD-10 Diagnosis: I700, I70201, I70202, I70203, I70209, I70211, I70212, I70213, I70219, I70221, I70222, I70223, I7025, I70229, I70231, I70232, I70233, I70234, I70235, I70238, I70239, I70241, I70242, I70243, I70244, I70245, I70248, I70249, I70261, I70262, I70263, I70269, I70291, I70292, I70293, I70299, I70301, I70302, I70303, I70309, I70311, I70312, I70313, I70319, I70321, I70322, I70323, I70329, I70331, I70332, I70333, I70334, I70335, I70338, I70339, I70341, I70342, I70343, I70344, I70345, I70348, I70349, I70361, I70362, I70363, I70369, I70391, I70392, I70393, I70399, I70401, I70402, I70403, I70409, I70411, I70412, I70413, I70419, I70421, I70422, I70423, I70429, I70431, I70432, I70433, I70434, I70435, I70438, I70439, I70441, I70442, I70443, I70444, I70445, I70448, I70449, I70461, I70462, I70463, I70469, I70491, I70492, I70493, I70499, I70501, I70502, I70503, I70509, I70511, I70512, I70513, I70519, I70521, I70522, I70523, I70529, I70531, I70532, I70533, I70534, I70535, I70538, I70539, I70541, I70542, I70543, I70544, I70545, I70548, I70549, I70561, I70562, I70563, I70569, I70591, I70592, I70593, I70599, I70601, I70602, I70603, I70609, I70611, I70612, I70613, I70619, I70621, I70622, I70623, I70629, I70631, I70632, I70633, I70634, I70635, I70638, I70639, I70641, I70642, I70643, I70644, I70645, I70648, I70649, I70661, I70662, I70663, I70669, I70691, I70692, I70693, I70699, I70701, I70702, I70703, I70709, I70711, I70712, I70713, I70719, I70721, I70722, I70723, I70729, I70731, I70732, I70733, I70734, I70735, I70738, I70739, I70741, I70742, I70743, I70744, I70745, I70748, I70749, I70761, I70762, I70763, I70769, I70791, I70792, I70793, I70799, I7092, I739, I771 CPT: 93668, 27290, 27295, 27590, 27592, 27594, 27596, 27598, 27880, 27881, 27882, 27884, 27886, 27888, 35302, 35303, 35304, 35305, 35306, 35331, 35351, 35355, 35361, 35363, 35371, 35372, 35452, 35454, 35456, 35459, 35470, 35472, 35473, 35474, 35481, 35482, 35483, 35485, 35491, 35492, 35493, 35495, 35521, 35533, 35537, 35538, 35539, 35540, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35637, 35638, 35646, 35647, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35876, 35879, 35881, 35883, 35884, 37220, 37221, 37222, 37223, 37224, 37225, 37226, 37227, 37228, 37229, 37230, 37231, 37232, 37233, 37234, 37235, 35381, 35541, 35546, 35582, 35651, 35641 ICD-9 Procedure: 38.18, 39.25, 39.29, 39.5, 39.9, 84.1, 84.12, 84.13, 84.14, 84.15, 84.16, 84.17, 84.18, 84.19, 84.3 ICD-10 Procedure: 041C***, 041D***, 041F***, 041H***, 041J***, 041K***, 041L***, 041M***, 041N***, 041U***, 0470***, 047C***, 047D***, 047E***, 047F***, 047H***, 047J***, 047K***, 047L***, 047M***, 047N***, 047P***, 047Q***, 047R***, 047S***, 047T***, 047U***, 047V***, 047W***, 047Y***, 04C0***, 04CC***, 04CD***, 04CE***, 04CF***, 04CH***, 04CJ***, 04CK***, 04CL***, 04CM***, 04CN***, 04CP***, 04CQ***, 04CR***, 04CS***, 04CT***, 04CU***, 04CV***, 04CW***, 04CY***, 0Y62***, 0Y63***, 0Y68***, 0Y6C***, 0Y6D***, 0Y6F***, 0Y6G***, 0Y6H***, 0Y6J***, 0Y6M***, 0Y6N*** Median = 2.32 years
[
  • 7,572 cases
  • , 111,595 controls
]
 — European — AllofUs —
PSS012041 ICD-9 Diagnosis: 4400, 44020, 44021, 44022, 44023, 44024, 44029, 44030, 44031, 44032, 4404, 4408, 4439, 4471 ICD-10 Diagnosis: I700, I70201, I70202, I70203, I70209, I70211, I70212, I70213, I70219, I70221, I70222, I70223, I7025, I70229, I70231, I70232, I70233, I70234, I70235, I70238, I70239, I70241, I70242, I70243, I70244, I70245, I70248, I70249, I70261, I70262, I70263, I70269, I70291, I70292, I70293, I70299, I70301, I70302, I70303, I70309, I70311, I70312, I70313, I70319, I70321, I70322, I70323, I70329, I70331, I70332, I70333, I70334, I70335, I70338, I70339, I70341, I70342, I70343, I70344, I70345, I70348, I70349, I70361, I70362, I70363, I70369, I70391, I70392, I70393, I70399, I70401, I70402, I70403, I70409, I70411, I70412, I70413, I70419, I70421, I70422, I70423, I70429, I70431, I70432, I70433, I70434, I70435, I70438, I70439, I70441, I70442, I70443, I70444, I70445, I70448, I70449, I70461, I70462, I70463, I70469, I70491, I70492, I70493, I70499, I70501, I70502, I70503, I70509, I70511, I70512, I70513, I70519, I70521, I70522, I70523, I70529, I70531, I70532, I70533, I70534, I70535, I70538, I70539, I70541, I70542, I70543, I70544, I70545, I70548, I70549, I70561, I70562, I70563, I70569, I70591, I70592, I70593, I70599, I70601, I70602, I70603, I70609, I70611, I70612, I70613, I70619, I70621, I70622, I70623, I70629, I70631, I70632, I70633, I70634, I70635, I70638, I70639, I70641, I70642, I70643, I70644, I70645, I70648, I70649, I70661, I70662, I70663, I70669, I70691, I70692, I70693, I70699, I70701, I70702, I70703, I70709, I70711, I70712, I70713, I70719, I70721, I70722, I70723, I70729, I70731, I70732, I70733, I70734, I70735, I70738, I70739, I70741, I70742, I70743, I70744, I70745, I70748, I70749, I70761, I70762, I70763, I70769, I70791, I70792, I70793, I70799, I7092, I739, I771 CPT: 93668, 27290, 27295, 27590, 27592, 27594, 27596, 27598, 27880, 27881, 27882, 27884, 27886, 27888, 35302, 35303, 35304, 35305, 35306, 35331, 35351, 35355, 35361, 35363, 35371, 35372, 35452, 35454, 35456, 35459, 35470, 35472, 35473, 35474, 35481, 35482, 35483, 35485, 35491, 35492, 35493, 35495, 35521, 35533, 35537, 35538, 35539, 35540, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35637, 35638, 35646, 35647, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35876, 35879, 35881, 35883, 35884, 37220, 37221, 37222, 37223, 37224, 37225, 37226, 37227, 37228, 37229, 37230, 37231, 37232, 37233, 37234, 37235, 35381, 35541, 35546, 35582, 35651, 35641 ICD-9 Procedure: 38.18, 39.25, 39.29, 39.5, 39.9, 84.1, 84.12, 84.13, 84.14, 84.15, 84.16, 84.17, 84.18, 84.19, 84.3 ICD-10 Procedure: 041C***, 041D***, 041F***, 041H***, 041J***, 041K***, 041L***, 041M***, 041N***, 041U***, 0470***, 047C***, 047D***, 047E***, 047F***, 047H***, 047J***, 047K***, 047L***, 047M***, 047N***, 047P***, 047Q***, 047R***, 047S***, 047T***, 047U***, 047V***, 047W***, 047Y***, 04C0***, 04CC***, 04CD***, 04CE***, 04CF***, 04CH***, 04CJ***, 04CK***, 04CL***, 04CM***, 04CN***, 04CP***, 04CQ***, 04CR***, 04CS***, 04CT***, 04CU***, 04CV***, 04CW***, 04CY***, 0Y62***, 0Y63***, 0Y68***, 0Y6C***, 0Y6D***, 0Y6F***, 0Y6G***, 0Y6H***, 0Y6J***, 0Y6M***, 0Y6N*** Median = 2.32 years
[
  • 1,652 cases
  • , 37,924 controls
]
 — Hispanic or Latin American — AllofUs —