Polygenic Score (PGS) ID: PGS005220

Predicted Trait
Reported Trait Obstructive sleep apnea (UnadjustedBMI)
Mapped Trait(s) obstructive sleep apnea (EFO_0003918)
Released in PGS Catalog: June 16, 2025
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Score Details

Score Construction
PGS Name PRS_BMIunadjOSA
Development Method
Name weighted PRSsummation PRS-CSs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 984,184
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000734
Citation (link to publication) Kurniansyah N et al. EBioMedicine (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 82.1%
African: 11.8%
Hispanic or Latin American: 5%
Additional Asian Ancestries: 0.9%
Not Reported: 0.1%
916,696 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • East Asian
  • Hispanic or Latin American
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90274865
Europe PMC: 36989840
 108,468 individuals African unspecified FinnGen, MGBB, MVP
GWAS Catalog: GCST90274865
Europe PMC: 36989840
 8,081 individuals Asian unspecified FinnGen, MGBB, MVP
GWAS Catalog: GCST90274865
Europe PMC: 36989840
 752,959 individuals European FinnGen, MGBB, MVP
GWAS Catalog: GCST90274865
Europe PMC: 36989840
 45,896 individuals Hispanic or Latin American FinnGen, MGBB, MVP
GWAS Catalog: GCST90274865
Europe PMC: 36989840
 1,292 individuals Not reported FinnGen, MGBB, MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022620 PSS012043|
Multi-ancestry (including European)|
21,975 individuals
 PGP000734 |
Kurniansyah N et al. EBioMedicine (2025)
 Reported Trait: Obstructive sleep apnea OR: 1.53 [1.39, 1.68] AUROC: 0.79 — age, sex, self-reported race/ethnicity , BMI and 11PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012043 — —
[
  • 4,463 cases
  • , 17,512 controls
]
,
47.0 % Male samples
 Mean = 53.0 years European, African American or Afro-Caribbean, East Asian, Hispanic or Latin American — OOA —